Design and Characterization of a PVLA-PEG-PVLA Thermosensitive and Biodegradable Hydrogel

Ajay Vidyasagar, Sook Hee Ku, Minchul Kim, Mihee Kim, Han Seung Lee, Timothy R. Pearce, Alon V. McCormick, Frank S. Bates, Efrosini Kokkoli

Research output: Contribution to journalArticle

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Abstract

A set of poly(δ-valerolactone-co-d,l-lactide)-b-poly(ethylene glycol)-b-poly(δ-valerolactone-co-d,l-lactide) (PVLA-PEG-PVLA) triblock copolymers was synthesized and the solution properties were characterized using rheology, cryo-TEM, cryo-SEM, SANS, and degradation studies. This polymer self-assembles into a low viscosity fluid with flowerlike spherical micelles in water at room temperature and transforms into a wormlike morphology upon heating, accompanied by gelation. At even higher temperatures syneresis is observed. At physiological temperature (37 °C) the hydrogel's average pore size is around 600 nm. The PVLA-PEG-PVLA gel degrades in about 45 days in cell media, making this unique hydrogel a promising candidate for biomedical applications.

Original languageEnglish (US)
Pages (from-to)1134-1139
Number of pages6
JournalACS Macro Letters
Volume6
Issue number10
DOIs
StatePublished - Oct 17 2017

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How much support was provided by MRSEC?

  • Partial

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  • Period 4

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