Design and Characterization of a PVLA-PEG-PVLA Thermosensitive and Biodegradable Hydrogel

Ajay Vidyasagar, Sook Hee Ku, Minchul Kim, Mihee Kim, Han Seung Lee, Timothy R. Pearce, Alon V. McCormick, Frank S. Bates, Efrosini Kokkoli

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A set of poly(δ-valerolactone-co-d,l-lactide)-b-poly(ethylene glycol)-b-poly(δ-valerolactone-co-d,l-lactide) (PVLA-PEG-PVLA) triblock copolymers was synthesized and the solution properties were characterized using rheology, cryo-TEM, cryo-SEM, SANS, and degradation studies. This polymer self-assembles into a low viscosity fluid with flowerlike spherical micelles in water at room temperature and transforms into a wormlike morphology upon heating, accompanied by gelation. At even higher temperatures syneresis is observed. At physiological temperature (37 °C) the hydrogel's average pore size is around 600 nm. The PVLA-PEG-PVLA gel degrades in about 45 days in cell media, making this unique hydrogel a promising candidate for biomedical applications.

Original languageEnglish (US)
Pages (from-to)1134-1139
Number of pages6
JournalACS Macro Letters
Volume6
Issue number10
DOIs
StatePublished - Oct 17 2017

Fingerprint

Hydrogel
Hydrogels
Polyethylene glycols
Gelation
Rheology
Micelles
Temperature
Block copolymers
Pore size
Gels
Viscosity
Transmission electron microscopy
Heating
Degradation
Polymers
Scanning electron microscopy
Fluids
poly-N-4-vinylbenzyllactonamide
Water
dilactide

How much support was provided by MRSEC?

  • Partial

Reporting period for MRSEC

  • Period 4

Cite this

Design and Characterization of a PVLA-PEG-PVLA Thermosensitive and Biodegradable Hydrogel. / Vidyasagar, Ajay; Ku, Sook Hee; Kim, Minchul; Kim, Mihee; Lee, Han Seung; Pearce, Timothy R.; McCormick, Alon V.; Bates, Frank S.; Kokkoli, Efrosini.

In: ACS Macro Letters, Vol. 6, No. 10, 17.10.2017, p. 1134-1139.

Research output: Contribution to journalArticle

Vidyasagar, Ajay ; Ku, Sook Hee ; Kim, Minchul ; Kim, Mihee ; Lee, Han Seung ; Pearce, Timothy R. ; McCormick, Alon V. ; Bates, Frank S. ; Kokkoli, Efrosini. / Design and Characterization of a PVLA-PEG-PVLA Thermosensitive and Biodegradable Hydrogel. In: ACS Macro Letters. 2017 ; Vol. 6, No. 10. pp. 1134-1139.
@article{83acb51077484f6da9d5724561bb9ca8,
title = "Design and Characterization of a PVLA-PEG-PVLA Thermosensitive and Biodegradable Hydrogel",
abstract = "A set of poly(δ-valerolactone-co-d,l-lactide)-b-poly(ethylene glycol)-b-poly(δ-valerolactone-co-d,l-lactide) (PVLA-PEG-PVLA) triblock copolymers was synthesized and the solution properties were characterized using rheology, cryo-TEM, cryo-SEM, SANS, and degradation studies. This polymer self-assembles into a low viscosity fluid with flowerlike spherical micelles in water at room temperature and transforms into a wormlike morphology upon heating, accompanied by gelation. At even higher temperatures syneresis is observed. At physiological temperature (37 °C) the hydrogel's average pore size is around 600 nm. The PVLA-PEG-PVLA gel degrades in about 45 days in cell media, making this unique hydrogel a promising candidate for biomedical applications.",
author = "Ajay Vidyasagar and Ku, {Sook Hee} and Minchul Kim and Mihee Kim and Lee, {Han Seung} and Pearce, {Timothy R.} and McCormick, {Alon V.} and Bates, {Frank S.} and Efrosini Kokkoli",
year = "2017",
month = "10",
day = "17",
doi = "10.1021/acsmacrolett.7b00523",
language = "English (US)",
volume = "6",
pages = "1134--1139",
journal = "ACS Macro Letters",
issn = "2161-1653",
publisher = "American Chemical Society",
number = "10",

}

TY - JOUR

T1 - Design and Characterization of a PVLA-PEG-PVLA Thermosensitive and Biodegradable Hydrogel

AU - Vidyasagar, Ajay

AU - Ku, Sook Hee

AU - Kim, Minchul

AU - Kim, Mihee

AU - Lee, Han Seung

AU - Pearce, Timothy R.

AU - McCormick, Alon V.

AU - Bates, Frank S.

AU - Kokkoli, Efrosini

PY - 2017/10/17

Y1 - 2017/10/17

N2 - A set of poly(δ-valerolactone-co-d,l-lactide)-b-poly(ethylene glycol)-b-poly(δ-valerolactone-co-d,l-lactide) (PVLA-PEG-PVLA) triblock copolymers was synthesized and the solution properties were characterized using rheology, cryo-TEM, cryo-SEM, SANS, and degradation studies. This polymer self-assembles into a low viscosity fluid with flowerlike spherical micelles in water at room temperature and transforms into a wormlike morphology upon heating, accompanied by gelation. At even higher temperatures syneresis is observed. At physiological temperature (37 °C) the hydrogel's average pore size is around 600 nm. The PVLA-PEG-PVLA gel degrades in about 45 days in cell media, making this unique hydrogel a promising candidate for biomedical applications.

AB - A set of poly(δ-valerolactone-co-d,l-lactide)-b-poly(ethylene glycol)-b-poly(δ-valerolactone-co-d,l-lactide) (PVLA-PEG-PVLA) triblock copolymers was synthesized and the solution properties were characterized using rheology, cryo-TEM, cryo-SEM, SANS, and degradation studies. This polymer self-assembles into a low viscosity fluid with flowerlike spherical micelles in water at room temperature and transforms into a wormlike morphology upon heating, accompanied by gelation. At even higher temperatures syneresis is observed. At physiological temperature (37 °C) the hydrogel's average pore size is around 600 nm. The PVLA-PEG-PVLA gel degrades in about 45 days in cell media, making this unique hydrogel a promising candidate for biomedical applications.

UR - http://www.scopus.com/inward/record.url?scp=85031698778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031698778&partnerID=8YFLogxK

U2 - 10.1021/acsmacrolett.7b00523

DO - 10.1021/acsmacrolett.7b00523

M3 - Article

AN - SCOPUS:85031698778

VL - 6

SP - 1134

EP - 1139

JO - ACS Macro Letters

JF - ACS Macro Letters

SN - 2161-1653

IS - 10

ER -