Design and applications of water irradiation devoid RF pulses for ultra-high field biomolecular NMR spectroscopy

V. S. Manu, Cristina Olivieri, Kowsalya Devi Pavuluri, Gianluigi Veglia

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Water suppression is of paramount importance for many biological and analytical NMR spectroscopy applications. Here, we report the design of a new set of binomial-like radio frequency (RF) pulses that elude water irradiation while exciting or refocusing the remainder of the 1H spectrum. These pulses were generated using a combination of an evolutionary algorithm and artificial intelligence. They display higher sensitivity relative to classical water suppression schemes and tunable water selectivity to avoid suppressing 1H resonances near the water signal. The broad bandwidth excitation obtained with these RF pulses makes them suitable for several NMR applications at high and ultra-high-field magnetic fields.

Original languageEnglish (US)
Pages (from-to)18477-18481
Number of pages5
JournalPhysical Chemistry Chemical Physics
Volume24
Issue number31
DOIs
StatePublished - Jul 19 2022

Bibliographical note

Funding Information:
This work was financially supported by the National Institute of Health (GM 64742, HL144130, 1S10OD021536 to GV). The experiments were carried out at the Minnesota NMR Center, University of Minnesota.

Publisher Copyright:
© 2022 The Royal Society of Chemistry.

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