Design and analysis of in vitro experiments for combination chemotherapy

Chap T Le, Patricia M. Grambsch

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A method is proposed for the evaluation of in vitro experiments for combination chemotherapy, a new and growing area of cancer research. We first describe and review a popular graphical device called an isobologram. We then propose a statistical framework, a simple experimental design, and a statistical test for use with this widely accepted methodology. The test we propose is a score test based on the linear logistic regression model.

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalJournal of Biopharmaceutical Statistics
Volume15
Issue number1
DOIs
StatePublished - Jan 31 2005

Keywords

  • Combination chemotherapy
  • Drug potency
  • Isobologram
  • Synergism

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