Desensitization protocol enabling pediatric crossmatch-positive renal transplantation: successful HLA-antibody-incompatible renal transplantation of two highly sensitized children

Anna M. Adamusiak; Jelena Stojanovic; Olivia Shaw; Robert Vaughan; Neil J. Sebire; Martin Drage; Nicos Kessaris; Stephen D. Marks; Nizam Mamode

doi:10.1007/s00467-016-3489-z

Desensitization protocol enabling pediatric crossmatch-positive renal transplantation: successful HLA-antibody-incompatible renal transplantation of two highly sensitized children

Anna M. Adamusiak, Jelena Stojanovic, Olivia Shaw, Robert Vaughan, Neil J. Sebire, Martin Drage, Nicos Kessaris, Stephen D. Marks, Nizam Mamode

Surgery

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5 Scopus citations

Abstract

Background: Renal transplantation improves quality of life (QoL) and survival in children requiring renal replacement therapy (RRT). Sensitization with development of a broad-spectrum of anti-HLA antibodies as a result of previous transplantation or after receiving blood products is an increasing problem. There are no published reports of desensitization protocols in children allowing renal transplantation from HLA-antibody-incompatible living donors. Methods: We adopted our well-established adult desensitization protocol for this purpose and undertook HLA antibody-incompatible living donor renal transplants in two children: a 14-year-old girl and a 13-year-old boy. Results: After 2 and 1.5 years of follow-up, respectively, both patients have stable renal allograft function despite a rise in donor-specific antibodies in one case. Conclusions: HLA-incompatible transplantation should be considered in selected cases for sensitized children.

Original language	English (US)
Pages (from-to)	359-364
Number of pages	6
Journal	Pediatric Nephrology
Volume	32
Issue number	2
DOIs	https://doi.org/10.1007/s00467-016-3489-z
State	Published - Feb 1 2017

Bibliographical note

Funding Information:
This research was supported in part by the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) based at Guy’s and St. Thomas’ NHS Foundation Trust and King’s College London, together with NIHR BRC based at Great Ormond Street Hospital in London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health.

Publisher Copyright:
© 2016, The Author(s).

Keywords

Antibody-incompatible HLA
Desensitization
Pediatric
Transplantation

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10.1007/s00467-016-3489-z

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203834

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Adamusiak, A. M., Stojanovic, J., Shaw, O., Vaughan, R., Sebire, N. J., Drage, M., Kessaris, N., Marks, S. D., & Mamode, N. (2017). Desensitization protocol enabling pediatric crossmatch-positive renal transplantation: successful HLA-antibody-incompatible renal transplantation of two highly sensitized children. Pediatric Nephrology, 32(2), 359-364. https://doi.org/10.1007/s00467-016-3489-z

Desensitization protocol enabling pediatric crossmatch-positive renal transplantation: successful HLA-antibody-incompatible renal transplantation of two highly sensitized children. / Adamusiak, Anna M.; Stojanovic, Jelena; Shaw, Olivia et al.
In: Pediatric Nephrology, Vol. 32, No. 2, 01.02.2017, p. 359-364.

Research output: Contribution to journal › Article › peer-review

Adamusiak, AM, Stojanovic, J, Shaw, O, Vaughan, R, Sebire, NJ, Drage, M, Kessaris, N, Marks, SD & Mamode, N 2017, 'Desensitization protocol enabling pediatric crossmatch-positive renal transplantation: successful HLA-antibody-incompatible renal transplantation of two highly sensitized children', Pediatric Nephrology, vol. 32, no. 2, pp. 359-364. https://doi.org/10.1007/s00467-016-3489-z

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abstract = "Background: Renal transplantation improves quality of life (QoL) and survival in children requiring renal replacement therapy (RRT). Sensitization with development of a broad-spectrum of anti-HLA antibodies as a result of previous transplantation or after receiving blood products is an increasing problem. There are no published reports of desensitization protocols in children allowing renal transplantation from HLA-antibody-incompatible living donors. Methods: We adopted our well-established adult desensitization protocol for this purpose and undertook HLA antibody-incompatible living donor renal transplants in two children: a 14-year-old girl and a 13-year-old boy. Results: After 2 and 1.5 years of follow-up, respectively, both patients have stable renal allograft function despite a rise in donor-specific antibodies in one case. Conclusions: HLA-incompatible transplantation should be considered in selected cases for sensitized children.",

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AU - Kessaris, Nicos

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N2 - Background: Renal transplantation improves quality of life (QoL) and survival in children requiring renal replacement therapy (RRT). Sensitization with development of a broad-spectrum of anti-HLA antibodies as a result of previous transplantation or after receiving blood products is an increasing problem. There are no published reports of desensitization protocols in children allowing renal transplantation from HLA-antibody-incompatible living donors. Methods: We adopted our well-established adult desensitization protocol for this purpose and undertook HLA antibody-incompatible living donor renal transplants in two children: a 14-year-old girl and a 13-year-old boy. Results: After 2 and 1.5 years of follow-up, respectively, both patients have stable renal allograft function despite a rise in donor-specific antibodies in one case. Conclusions: HLA-incompatible transplantation should be considered in selected cases for sensitized children.

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Desensitization protocol enabling pediatric crossmatch-positive renal transplantation: successful HLA-antibody-incompatible renal transplantation of two highly sensitized children

Abstract

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