Background: Renal transplantation improves quality of life (QoL) and survival in children requiring renal replacement therapy (RRT). Sensitization with development of a broad-spectrum of anti-HLA antibodies as a result of previous transplantation or after receiving blood products is an increasing problem. There are no published reports of desensitization protocols in children allowing renal transplantation from HLA-antibody-incompatible living donors. Methods: We adopted our well-established adult desensitization protocol for this purpose and undertook HLA antibody-incompatible living donor renal transplants in two children: a 14-year-old girl and a 13-year-old boy. Results: After 2 and 1.5 years of follow-up, respectively, both patients have stable renal allograft function despite a rise in donor-specific antibodies in one case. Conclusions: HLA-incompatible transplantation should be considered in selected cases for sensitized children.
Bibliographical noteFunding Information:
This research was supported in part by the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) based at Guy’s and St. Thomas’ NHS Foundation Trust and King’s College London, together with NIHR BRC based at Great Ormond Street Hospital in London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health.
© 2016, The Author(s).
- Antibody-incompatible HLA