Desensitization protocol enabling pediatric crossmatch-positive renal transplantation: successful HLA-antibody-incompatible renal transplantation of two highly sensitized children

Anna M. Adamusiak, Jelena Stojanovic, Olivia Shaw, Robert Vaughan, Neil J. Sebire, Martin Drage, Nicos Kessaris, Stephen D. Marks, Nizam Mamode

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Renal transplantation improves quality of life (QoL) and survival in children requiring renal replacement therapy (RRT). Sensitization with development of a broad-spectrum of anti-HLA antibodies as a result of previous transplantation or after receiving blood products is an increasing problem. There are no published reports of desensitization protocols in children allowing renal transplantation from HLA-antibody-incompatible living donors. Methods: We adopted our well-established adult desensitization protocol for this purpose and undertook HLA antibody-incompatible living donor renal transplants in two children: a 14-year-old girl and a 13-year-old boy. Results: After 2 and 1.5 years of follow-up, respectively, both patients have stable renal allograft function despite a rise in donor-specific antibodies in one case. Conclusions: HLA-incompatible transplantation should be considered in selected cases for sensitized children.

Original languageEnglish (US)
Pages (from-to)359-364
Number of pages6
JournalPediatric Nephrology
Volume32
Issue number2
DOIs
StatePublished - Feb 1 2017

Keywords

  • Antibody-incompatible HLA
  • Desensitization
  • Pediatric
  • Transplantation

Fingerprint Dive into the research topics of 'Desensitization protocol enabling pediatric crossmatch-positive renal transplantation: successful HLA-antibody-incompatible renal transplantation of two highly sensitized children'. Together they form a unique fingerprint.

Cite this