Dermatomyositis-like muscle pathology in patients with chronic graft-versus-host disease

Jeffrey A. Allen, Steven A. Greenberg, Anthony A. Amato

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Myositis is a rare complication of chronic graft-versus-host disease (cGVHD) following hematopoietic stem cell transplantation (HSCT). Almost all such patients have been reported to have polymyositis (PM). We describe clinical, pathologic, and molecular studies of 3 patients with cGVHD following allogeneic HSCT who developed myopathy. In each case, perifascicular atrophy, the pathognomonic histologic feature of dermatomyositis (DM), was observed.

Original languageEnglish (US)
Pages (from-to)643-647
Number of pages5
JournalMuscle and Nerve
Volume40
Issue number4
DOIs
StatePublished - Oct 1 2009

Keywords

  • Chronic graft-versus-host disease
  • Dermatomyositis
  • Hematopoietic stem cell transplantation
  • Myositis
  • Perifascicular atrophy

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