Derivation and validation of diagnostic criteria for chronic inflammatory demyelinating polyneuropathy

C. L. Koski, M. Baumgarten, L. S. Magder, R. J. Barohn, J. Goldstein, M. Graves, K. Gorson, A. F. Hahn, R. A.C. Hughes, J. Katz, R. A. Lewis, Gareth J Parry, P. van Doorn, D. R. Cornblath

Research output: Contribution to journalReview article

90 Scopus citations

Abstract

To develop diagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP), a retrospective series of patients' records diagnosed by sexpert consensus as CIDP or other chronic polyneuropathies were analyzed. Classification and regression tree analysis was applied to 150 patients to derive a classification rule. According to the rule, diagnosis of CIDP required that a patient have a chronic non-genetic polyneuropathy, progressive for at least eight weeks, without a serum paraprotein and either 1) recordable compound muscle action potentials in ≥ 75% of motor nerves and either abnormal distal latency in > 50% of nerves or abnormal motor conduction velocity in > 50% of nerves or abnormal F wave latency in > 50% of nerves; or 2) symmetrical onset of motor symptoms, symmetrical weakness of four limbs, and proximal weakness in ≥ 1 limb. When validated in 117 patients, the rule had 83% sensitivity (95% confidence interval 69%-93%) and 97% specificity (95% confidence interval 89%-99%) and performed better than published criteria.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of the Neurological Sciences
Volume277
Issue number1-2
DOIs
StatePublished - Feb 15 2009

Keywords

  • CART analysis
  • CIDP
  • Diagnostic criteria

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    Koski, C. L., Baumgarten, M., Magder, L. S., Barohn, R. J., Goldstein, J., Graves, M., Gorson, K., Hahn, A. F., Hughes, R. A. C., Katz, J., Lewis, R. A., Parry, G. J., van Doorn, P., & Cornblath, D. R. (2009). Derivation and validation of diagnostic criteria for chronic inflammatory demyelinating polyneuropathy. Journal of the Neurological Sciences, 277(1-2), 1-8. https://doi.org/10.1016/j.jns.2008.11.015