Depurinating acylfulvene-DNA adducts: Characterizing cellular chemical reactions of a selective antitumor agent

Keyphrases

• DNA Adducts 100%
• Antitumor Agents 100%
• Chemical Reaction 100%
• Acylfulvene 100%
• Oxidoreductase 25%
• DNA Alkylation 25%
• Alkenals 25%
• Cytotoxicity 16%
• Alkylation 16%
• Alkyl 16%
• Cellular DNA 16%
• Naked DNA 16%
• Clinical Trials 8%
• Structure-property Relationships 8%
• Tumor Cells 8%
• Semi-synthetic 8%
• In Vitro Study 8%
• Bioactivation 8%
• Chemical Synthesis 8%
• Chemical Properties 8%
• Reaction Pathway 8%
• Structural Characterization 8%
• Single-stranded DNA (ssDNA) 8%
• Nucleosides 8%
• Nucleobases 8%
• DNA Cleavage 8%
• Physiologically Relevant Conditions 8%
• Hydrolytic 8%
• Control Vector 8%
• Cell Sensitivity 8%
• DNA Evidence 8%
• Conjugate Addition 8%
• Competing Reactions 8%
• Level-sensitivity 8%
• Cyclopropane Ring Opening 8%
• Bioreductive Activation 8%
• High Toxicity 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Anticarcinogen 100%
• Oxidoreductase 100%
• Cell DNA 66%
• Naked DNA 66%
• Cytotoxicity 66%
• Clinical Trial 33%
• Bioactivation 33%
• Irofulven 33%
• Nucleic Acid Base 33%
• Single Stranded DNA 33%
• Neoplasm 33%
• Nucleoside 33%
• Cyclopropane 33%

Chemistry

• Antineoplastic Agent 100%
• Deoxyribonucleic Acid 100%
• DNA Alkylation 37%
• Nucleoside 12%
• Ring Opening Reaction 12%
• Cyclopropane Ring 12%
• Single-Stranded DNA 12%
• Nucleobase 12%
• stability 12%
• formation 12%
• hydrolytic 12%