Depth-resolved measurement of transient structural changes during action potential propagation

Taner Akkin, Chulmin Joo, Johannes F. De Boer

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


We report noncontact optical measurement of fast transient structural changes in the crustacean nerve during action potential propagation without the need for exogenous chemicals or re.ection coatings. The technique, spectral domain optical coherence tomography, provides real-time cross-sectional images of the nerve with micron-scale resolution to select a specific region for functional assessment and interferometric phase sensitivity for subnanometer-scale motion detection. Noncontact optical measurements demonstrate nanometer-scale transient movement on a 1-ms timescale associated with action potential propagation in and lobster nerves.

Original languageEnglish (US)
Pages (from-to)1347-1353
Number of pages7
JournalBiophysical journal
Issue number4
StatePublished - Aug 2007

Bibliographical note

Funding Information:
This research was supported by National Institutes of Health grant R01-EY014975 and R01-RR19768.


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