Depressive symptoms modulate the subjective and physiological response to cocaine in humans

Mehmet Sofuoglu, Scott Brown, David A. Babb, Dorothy K. Hatsukami

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The goal of this study was to examine the relationship between the presence of subclinical depressive symptoms and physiological and subjective responses to smoked cocaine in humans. Cocaine users without major depression, who participated in various inpatient studies, received a single 0.4 mg/kg of smoked cocaine. When the relationship between the Beck Depression Inventory (BDI) scores and various subjective and physiological responses to cocaine was examined, similar trends were found. Low BDI scores of 0-7 were associated with a smaller physiological and subjective cocaine response. In contrast, BDI ranges of 8-13 were associated with enhanced cocaine response which plateaued or declined in the higher ( > 14) BDI group. These group differences were not explained by sex or body weight differences among groups. The implication of these results is that the presence of depressive symptoms may affect cocaine use behavior partly by being associated with an enhanced response to cocaine.

Original languageEnglish (US)
Pages (from-to)131-137
Number of pages7
JournalDrug and alcohol dependence
Issue number2
StatePublished - Jul 1 2001

Bibliographical note

Funding Information:
This research was supported by grants from the National Institute on Drug Abuse (P-50 DA09259) and from the National Center for Research Resources (MO1-RR00400). We would like to thank the General Clinical Research Center nursing staff for technical assistance.


  • Cocaine
  • Depression
  • Depressive symptoms
  • Physiological response
  • Subjective response


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