Depressive symptoms are related to progression of coronary calcium in midlife women

The Study of Women's Health Across the Nation (SWAN) Heart Study

Imke Janssen, Lynda H. Powell, Karen A. Matthews, John F. Cursio, Steven M. Hollenberg, Kim Sutton-Tyrrell, Joyce T. Bromberger, Susan A. Everson-Rose

Research output: Contribution to journalArticle

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Abstract

Background: Major depression and depressive symptoms are associated with cardiovascular disease (CVD), but the impact of depression on early atherogenesis is less well known, particularly in women and minorities. This study examined whether depressive symptoms are associated with progression of coronary artery calcification (CAC) among women at midlife. Methods: The SWAN is a longitudinal, multisite study assessing health and psychologic factors in midlife women. An ancillary study (SWAN Heart) evaluated subclinical atherosclerosis in women who reported no history of CVD or diabetes. In 346 women, CAC was measured twice by electron beam computed tomography, an average of 2.3 years apart. Progression, defined as an increase by ≥10 Agatston units, was analyzed using relative risk (RR) regression. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression (CES-D) Scale. Results: Progression of CAC was observed in 67 women (19.1%). Each 1-SD-higher CES-D score at baseline related to a 25% increased risk of CAC progression (RR 1.25, 95% CI 1.06-1.47, P = .007), adjusting for age, time between scans, ethnicity, education, menopausal status, and known CVD risk factors. This risk was similar to the risk induced by body mass index (RR 1.31, 95% CI 1.11-1.54, P = .001) and systolic blood pressure (RR 1.28, 95% CI 1.06-1.55, P = .01). Conclusions: Depressive symptoms were independently associated with progression of CAC in this cohort of midlife women. Depressive symptoms may represent a risk factor that is potentially modifiable for early prevention of CVD in women.

Original languageEnglish (US)
JournalAmerican Heart Journal
Volume161
Issue number6
DOIs
StatePublished - Jan 1 2011

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Women's Health
Depression
Calcium
Coronary Vessels
Cardiovascular Diseases
Epidemiologic Studies
Atherosclerosis
Blood Pressure
X Ray Computed Tomography
Longitudinal Studies
Body Mass Index
Education
Health

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Depressive symptoms are related to progression of coronary calcium in midlife women : The Study of Women's Health Across the Nation (SWAN) Heart Study. / Janssen, Imke; Powell, Lynda H.; Matthews, Karen A.; Cursio, John F.; Hollenberg, Steven M.; Sutton-Tyrrell, Kim; Bromberger, Joyce T.; Everson-Rose, Susan A.

In: American Heart Journal, Vol. 161, No. 6, 01.01.2011.

Research output: Contribution to journalArticle

Janssen, Imke ; Powell, Lynda H. ; Matthews, Karen A. ; Cursio, John F. ; Hollenberg, Steven M. ; Sutton-Tyrrell, Kim ; Bromberger, Joyce T. ; Everson-Rose, Susan A. / Depressive symptoms are related to progression of coronary calcium in midlife women : The Study of Women's Health Across the Nation (SWAN) Heart Study. In: American Heart Journal. 2011 ; Vol. 161, No. 6.
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title = "Depressive symptoms are related to progression of coronary calcium in midlife women: The Study of Women's Health Across the Nation (SWAN) Heart Study",
abstract = "Background: Major depression and depressive symptoms are associated with cardiovascular disease (CVD), but the impact of depression on early atherogenesis is less well known, particularly in women and minorities. This study examined whether depressive symptoms are associated with progression of coronary artery calcification (CAC) among women at midlife. Methods: The SWAN is a longitudinal, multisite study assessing health and psychologic factors in midlife women. An ancillary study (SWAN Heart) evaluated subclinical atherosclerosis in women who reported no history of CVD or diabetes. In 346 women, CAC was measured twice by electron beam computed tomography, an average of 2.3 years apart. Progression, defined as an increase by ≥10 Agatston units, was analyzed using relative risk (RR) regression. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression (CES-D) Scale. Results: Progression of CAC was observed in 67 women (19.1{\%}). Each 1-SD-higher CES-D score at baseline related to a 25{\%} increased risk of CAC progression (RR 1.25, 95{\%} CI 1.06-1.47, P = .007), adjusting for age, time between scans, ethnicity, education, menopausal status, and known CVD risk factors. This risk was similar to the risk induced by body mass index (RR 1.31, 95{\%} CI 1.11-1.54, P = .001) and systolic blood pressure (RR 1.28, 95{\%} CI 1.06-1.55, P = .01). Conclusions: Depressive symptoms were independently associated with progression of CAC in this cohort of midlife women. Depressive symptoms may represent a risk factor that is potentially modifiable for early prevention of CVD in women.",
author = "Imke Janssen and Powell, {Lynda H.} and Matthews, {Karen A.} and Cursio, {John F.} and Hollenberg, {Steven M.} and Kim Sutton-Tyrrell and Bromberger, {Joyce T.} and Everson-Rose, {Susan A.}",
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AU - Powell, Lynda H.

AU - Matthews, Karen A.

AU - Cursio, John F.

AU - Hollenberg, Steven M.

AU - Sutton-Tyrrell, Kim

AU - Bromberger, Joyce T.

AU - Everson-Rose, Susan A.

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N2 - Background: Major depression and depressive symptoms are associated with cardiovascular disease (CVD), but the impact of depression on early atherogenesis is less well known, particularly in women and minorities. This study examined whether depressive symptoms are associated with progression of coronary artery calcification (CAC) among women at midlife. Methods: The SWAN is a longitudinal, multisite study assessing health and psychologic factors in midlife women. An ancillary study (SWAN Heart) evaluated subclinical atherosclerosis in women who reported no history of CVD or diabetes. In 346 women, CAC was measured twice by electron beam computed tomography, an average of 2.3 years apart. Progression, defined as an increase by ≥10 Agatston units, was analyzed using relative risk (RR) regression. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression (CES-D) Scale. Results: Progression of CAC was observed in 67 women (19.1%). Each 1-SD-higher CES-D score at baseline related to a 25% increased risk of CAC progression (RR 1.25, 95% CI 1.06-1.47, P = .007), adjusting for age, time between scans, ethnicity, education, menopausal status, and known CVD risk factors. This risk was similar to the risk induced by body mass index (RR 1.31, 95% CI 1.11-1.54, P = .001) and systolic blood pressure (RR 1.28, 95% CI 1.06-1.55, P = .01). Conclusions: Depressive symptoms were independently associated with progression of CAC in this cohort of midlife women. Depressive symptoms may represent a risk factor that is potentially modifiable for early prevention of CVD in women.

AB - Background: Major depression and depressive symptoms are associated with cardiovascular disease (CVD), but the impact of depression on early atherogenesis is less well known, particularly in women and minorities. This study examined whether depressive symptoms are associated with progression of coronary artery calcification (CAC) among women at midlife. Methods: The SWAN is a longitudinal, multisite study assessing health and psychologic factors in midlife women. An ancillary study (SWAN Heart) evaluated subclinical atherosclerosis in women who reported no history of CVD or diabetes. In 346 women, CAC was measured twice by electron beam computed tomography, an average of 2.3 years apart. Progression, defined as an increase by ≥10 Agatston units, was analyzed using relative risk (RR) regression. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression (CES-D) Scale. Results: Progression of CAC was observed in 67 women (19.1%). Each 1-SD-higher CES-D score at baseline related to a 25% increased risk of CAC progression (RR 1.25, 95% CI 1.06-1.47, P = .007), adjusting for age, time between scans, ethnicity, education, menopausal status, and known CVD risk factors. This risk was similar to the risk induced by body mass index (RR 1.31, 95% CI 1.11-1.54, P = .001) and systolic blood pressure (RR 1.28, 95% CI 1.06-1.55, P = .01). Conclusions: Depressive symptoms were independently associated with progression of CAC in this cohort of midlife women. Depressive symptoms may represent a risk factor that is potentially modifiable for early prevention of CVD in women.

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