Abstract
Incubation of bovine peripheral blood monocytes with bovine viral diarrhea virus (either Singer or NY-1 strain) caused a consistent, statistically significant decrease in their random locomotion (no chemoattractant) and chemotaxis towards a chemotactic lymphokine. Chemotaxis was determined by a modification of the Boyden method. Incubation of bovine viral diarrhea virus with mononuclear cells depressed chemotaxis by a mean of 56% (P < 0.0005). Heat-killed virus had no effect on monocyte motility. Data suggest that bovine viral diarrhea virus can rapidly suppress monocyte functions in vitro, but by unknown mechanisms, not by killing cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 565-568 |
| Number of pages | 4 |
| Journal | Infection and immunity |
| Volume | 25 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1979 |