TY - JOUR
T1 - Depression of bovine monocyte chemotactic responses by bovine viral diarrhea virus
AU - Ketelsen, A. T.
AU - Johnson, D. W.
AU - Muscoplat, Charles C
PY - 1979
Y1 - 1979
N2 - Incubation of bovine peripheral blood monocytes with bovine viral diarrhea virus (either Singer or NY-1 strain) caused a consistent, statistically significant decrease in their random locomotion (no chemoattractant) and chemotaxis towards a chemotactic lymphokine. Chemotaxis was determined by a modification of the Boyden method. Incubation of bovine viral diarrhea virus with mononuclear cells depressed chemotaxis by a mean of 56% (P < 0.0005). Heat-killed virus had no effect on monocyte motility. Data suggest that bovine viral diarrhea virus can rapidly suppress monocyte functions in vitro, but by unknown mechanisms, not by killing cells.
AB - Incubation of bovine peripheral blood monocytes with bovine viral diarrhea virus (either Singer or NY-1 strain) caused a consistent, statistically significant decrease in their random locomotion (no chemoattractant) and chemotaxis towards a chemotactic lymphokine. Chemotaxis was determined by a modification of the Boyden method. Incubation of bovine viral diarrhea virus with mononuclear cells depressed chemotaxis by a mean of 56% (P < 0.0005). Heat-killed virus had no effect on monocyte motility. Data suggest that bovine viral diarrhea virus can rapidly suppress monocyte functions in vitro, but by unknown mechanisms, not by killing cells.
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U2 - 10.1128/iai.25.2.565-568.1979
DO - 10.1128/iai.25.2.565-568.1979
M3 - Article
C2 - 226479
AN - SCOPUS:0018751291
SN - 0019-9567
VL - 25
SP - 565
EP - 568
JO - Infection and immunity
JF - Infection and immunity
IS - 2
ER -