Depression of bovine monocyte chemotactic responses by bovine viral diarrhea virus

A. T. Ketelsen, D. W. Johnson, Charles C Muscoplat

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Incubation of bovine peripheral blood monocytes with bovine viral diarrhea virus (either Singer or NY-1 strain) caused a consistent, statistically significant decrease in their random locomotion (no chemoattractant) and chemotaxis towards a chemotactic lymphokine. Chemotaxis was determined by a modification of the Boyden method. Incubation of bovine viral diarrhea virus with mononuclear cells depressed chemotaxis by a mean of 56% (P < 0.0005). Heat-killed virus had no effect on monocyte motility. Data suggest that bovine viral diarrhea virus can rapidly suppress monocyte functions in vitro, but by unknown mechanisms, not by killing cells.

Original languageEnglish (US)
Pages (from-to)565-568
Number of pages4
JournalInfection and immunity
Volume25
Issue number2
DOIs
StatePublished - 1979

Fingerprint

Dive into the research topics of 'Depression of bovine monocyte chemotactic responses by bovine viral diarrhea virus'. Together they form a unique fingerprint.

Cite this