This paper reports on an experimental study of the deposition of well-characterized silica agglomerates in a cast of a section of a human lung. Deposition of the agglomerates is compared with the deposition of oleic acid spheres and sodium chloride particles for a range of mobility sizes, agglomerate properties (primary particle size and mass-mobility exponent) and inspiratory flow rates. In most cases, agglomerate deposition was significantly greater than that of the oleic acid and sodium chloride particles. Deposition of agglomerates with a more open structure was greater than that of relatively more compact (but still non-spherical) agglomerates. Deposition also increased with the flow rate. Because of the large physical size of the agglomerates, as well as the crenulated flow path through the model and the flow rate dependence, it is likely that interception is responsible for the enhanced deposition of the agglomerates.
Bibliographical noteFunding Information:
This work was supported by the National Science Foundation , Grant BES-0646507 . Electron microscopy was performed at the University of Minnesota College of Science and Engineering's Characterization Facility with the assistance of Dr. Lejun Qi and Ranganathan Gopalakrishnan. Dr. Michael Oldham, Community & Environmental Medicine, UC Irvine, generously provided the cast of the human lung section used in this study.
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- Lung deposition