Dependence of tablet brittleness on tensile strength and porosity

Xingchu Gong, Shao Yu Chang, Frederick Osei-Yeboah, Shubhajit Paul, Sathyanarayana Reddy Perumalla, Limin Shi, Wei Jhe Sun, Qun Zhou, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Abstract An analysis of data collected from 25 sets of diverse pharmaceutical powders has identified that an exponential growth function satisfactorily describes the relationship between tablet brittleness and tablet porosity while a power law function well describes the relationship between tablet brittleness and tensile strength. These equations have the potential to facilitate better characterization of tablet mechanical properties and to guide the design and optimization of pharmaceutical tablet products.

Original languageEnglish (US)
Article number15054
Pages (from-to)208-213
Number of pages6
JournalInternational journal of pharmaceutics
Volume493
Issue number1-2
DOIs
StatePublished - Aug 10 2015

Keywords

  • Brittleness
  • Porosity
  • Tablet
  • Tensile strength

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