Dependence of tablet brittleness on tensile strength and porosity

Xingchu Gong; Shao Yu Chang; Frederick Osei-Yeboah; Shubhajit Paul; Sathyanarayana Reddy Perumalla; Limin Shi; Wei Jhe Sun; Qun Zhou; Changquan Calvin Sun

doi:10.1016/j.ijpharm.2015.07.050

Dependence of tablet brittleness on tensile strength and porosity

Xingchu Gong, Shao Yu Chang, Frederick Osei-Yeboah, Shubhajit Paul, Sathyanarayana Reddy Perumalla, Limin Shi, Wei Jhe Sun, Qun Zhou, Changquan Calvin Sun

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Abstract An analysis of data collected from 25 sets of diverse pharmaceutical powders has identified that an exponential growth function satisfactorily describes the relationship between tablet brittleness and tablet porosity while a power law function well describes the relationship between tablet brittleness and tensile strength. These equations have the potential to facilitate better characterization of tablet mechanical properties and to guide the design and optimization of pharmaceutical tablet products.

Original language	English (US)
Article number	15054
Pages (from-to)	208-213
Number of pages	6
Journal	International journal of pharmaceutics
Volume	493
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2015.07.050
State	Published - Aug 10 2015

Bibliographical note

Funding Information:
X.G. is grateful to the Young Teacher Training Program of Zhejiang University.

Publisher Copyright:
© 2015 Elsevier B.V.

Keywords

Brittleness
Porosity
Tablet
Tensile strength

Publisher link

10.1016/j.ijpharm.2015.07.050

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title = "Dependence of tablet brittleness on tensile strength and porosity",

abstract = "Abstract An analysis of data collected from 25 sets of diverse pharmaceutical powders has identified that an exponential growth function satisfactorily describes the relationship between tablet brittleness and tablet porosity while a power law function well describes the relationship between tablet brittleness and tensile strength. These equations have the potential to facilitate better characterization of tablet mechanical properties and to guide the design and optimization of pharmaceutical tablet products.",

keywords = "Brittleness, Porosity, Tablet, Tensile strength",

author = "Xingchu Gong and Chang, {Shao Yu} and Frederick Osei-Yeboah and Shubhajit Paul and Perumalla, {Sathyanarayana Reddy} and Limin Shi and Sun, {Wei Jhe} and Qun Zhou and Sun, {Changquan Calvin}",

note = "Funding Information: X.G. is grateful to the Young Teacher Training Program of Zhejiang University. Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

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doi = "10.1016/j.ijpharm.2015.07.050",

language = "English (US)",

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AU - Gong, Xingchu

AU - Chang, Shao Yu

AU - Osei-Yeboah, Frederick

AU - Paul, Shubhajit

AU - Perumalla, Sathyanarayana Reddy

AU - Shi, Limin

AU - Sun, Wei Jhe

AU - Zhou, Qun

AU - Sun, Changquan Calvin

PY - 2015/8/10

Y1 - 2015/8/10

N2 - Abstract An analysis of data collected from 25 sets of diverse pharmaceutical powders has identified that an exponential growth function satisfactorily describes the relationship between tablet brittleness and tablet porosity while a power law function well describes the relationship between tablet brittleness and tensile strength. These equations have the potential to facilitate better characterization of tablet mechanical properties and to guide the design and optimization of pharmaceutical tablet products.

AB - Abstract An analysis of data collected from 25 sets of diverse pharmaceutical powders has identified that an exponential growth function satisfactorily describes the relationship between tablet brittleness and tablet porosity while a power law function well describes the relationship between tablet brittleness and tensile strength. These equations have the potential to facilitate better characterization of tablet mechanical properties and to guide the design and optimization of pharmaceutical tablet products.

KW - Brittleness

KW - Porosity

KW - Tablet

KW - Tensile strength

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ER -

Dependence of tablet brittleness on tensile strength and porosity

Abstract

Bibliographical note

Keywords

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