Dendrimeric gadolinium chelate with fast water exchange and high relaxivity at high magnetic field strength

Valérie C. Pierre; Mauro Botta; Kenneth N. Raymond

doi:10.1021/ja045263y

Dendrimeric gadolinium chelate with fast water exchange and high relaxivity at high magnetic field strength

Valérie C. Pierre, Mauro Botta, Kenneth N. Raymond

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

The synthesis and relaxivity properties of a new dendrimeric Gd chelate, Gd-TREN-bisHOPO-TAM-Asp-Asp₂-12OH, are presented. The macromolecule demonstrates improved water solubility due to its 12 terminal hydroxyl groups and improved relaxivity due to its optimal water exchange rate and slower molecular tumbling. Unprecedented high relaxivity (r_1p = 18 mM^-1 s^-1) is observed at high magnetic field (90 MHz), an important advance in the development of contrast agents for the next generation of MRI scanners.

Original language	English (US)
Pages (from-to)	504-505
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	127
Issue number	2
DOIs	https://doi.org/10.1021/ja045263y
State	Published - Jan 19 2005

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10.1021/ja045263y

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abstract = "The synthesis and relaxivity properties of a new dendrimeric Gd chelate, Gd-TREN-bisHOPO-TAM-Asp-Asp2-12OH, are presented. The macromolecule demonstrates improved water solubility due to its 12 terminal hydroxyl groups and improved relaxivity due to its optimal water exchange rate and slower molecular tumbling. Unprecedented high relaxivity (r1p = 18 mM-1 s-1) is observed at high magnetic field (90 MHz), an important advance in the development of contrast agents for the next generation of MRI scanners.",

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AU - Pierre, Valérie C.

AU - Botta, Mauro

AU - Raymond, Kenneth N.

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Y1 - 2005/1/19

N2 - The synthesis and relaxivity properties of a new dendrimeric Gd chelate, Gd-TREN-bisHOPO-TAM-Asp-Asp2-12OH, are presented. The macromolecule demonstrates improved water solubility due to its 12 terminal hydroxyl groups and improved relaxivity due to its optimal water exchange rate and slower molecular tumbling. Unprecedented high relaxivity (r1p = 18 mM-1 s-1) is observed at high magnetic field (90 MHz), an important advance in the development of contrast agents for the next generation of MRI scanners.

AB - The synthesis and relaxivity properties of a new dendrimeric Gd chelate, Gd-TREN-bisHOPO-TAM-Asp-Asp2-12OH, are presented. The macromolecule demonstrates improved water solubility due to its 12 terminal hydroxyl groups and improved relaxivity due to its optimal water exchange rate and slower molecular tumbling. Unprecedented high relaxivity (r1p = 18 mM-1 s-1) is observed at high magnetic field (90 MHz), an important advance in the development of contrast agents for the next generation of MRI scanners.

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Dendrimeric gadolinium chelate with fast water exchange and high relaxivity at high magnetic field strength

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