Demultiplexing of Magnetic Nanowires with Overlapping Signatures for Tagged Biological Species

Reza Zamani, Joseph Um, Bethanie J.H. Stadler

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The drive to comprehend nanomedicine and biology with a reliable technique for multiplexed detection of biological entities, such as biocompatible membranes, regenerative tissues, and cells, demands much of the current state-of-the-art technologies. Angular-dependent coercivity (ADC) and first-order reversal curve (FORC) measurements are frequently used for the identification of magnetic nanowires (MNWs), but a robust framework for quantitative demultiplexing of signals is still lacking. In this paper, we first extracted quantitative characteristics from ADC and FORC measured on samples including a single type of MNW. We then analyzed the ability of these characteristics for quantitative demultiplexing combinations of MNWs. Backfield remanence magnetization was determined as the most reliable characteristic for quantitative multiplexing applications. Our approach envisions an insightful pathway for accurate quantitative identification of biocompatible membranes labeled with MNWs, even if their magnetic signatures overlap. Very small volume ratios of multiplexed labels were detected without requiring fluorophores, which opens a future for cellular multiplexing as well.

Original languageEnglish (US)
Pages (from-to)3080-3087
Number of pages8
JournalACS Applied Nano Materials
Issue number3
StatePublished - Mar 27 2020

Bibliographical note

Funding Information:
This work is based upon the work supported primarily by the National Science Foundation under grant no. CMMI-1762884. Portions of this work were conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under award number ECCS-1542202. Part of this work was performed at the Institute for Rock Magnetism (IRM) at the University of Minnesota. The IRM is a US National Multi-user Facility supported through the Instrumentation and Facilities program of the National Science Foundation, Earth Sciences Division (NSF/EAR 1642268), and by funding from the University of Minnesota.

Publisher Copyright:
Copyright © 2020 American Chemical Society


  • ADC measurement
  • FORC measurement
  • magnetic biolabels
  • magnetic characteristic
  • magnetic nanowires
  • multiplexing


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