TY - JOUR
T1 - Demonstration of Interleukin 6 in Middle Ear Effusions
AU - Yellon, Robert F.
AU - Leonard, Gerald
AU - Sidman, James
AU - Carpenter, Robert
AU - Burleson, Joseph
AU - Marucha, Phillip
AU - Kreutzer, Donald
AU - Carlson, James
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1992/7
Y1 - 1992/7
N2 - In response to infection in the middle ear, inflammatory cells produce cytokines-potent regulators and mediators of the immune response. In an earlier study, we demonstrated that levels of the cytokine interleukin 1 were higher in middle-ear effusions from younger children, while levels of the cytokine tumor necrosis factor were higher in middle-ear effusions from older children and in those requiring tympanostomy on multiple occasions. In this study, we evaluated middle-ear effusions for levels of the cytokine interleukin 6. Activities of interleukin 6 include stimulation of bone erosion and production of antibodies and fever. Using an enzyme-linked immunosorbent assay system, significant levels of interleukin 6 (>0.2 pg/mL) were found in 14 (36%) of 39 middle-ear effusions from 25 children with otitis media with effusion. The mean (±SE) level of interleukin 6 in middle-ear effusions was 173.9± 74.7 pg/mg of total protein. Like interleukin 1, levels of interleukin 6 were higher in younger children. Tumor necrosis factor may be an important regulator of the local immune response in the middle-ear cleft during persistence of otitis media with effusion, while interleukin 1 and interleukin 6 may be important regulators during the early stages of otitis media with effusion. (Arch Otolaryngol Head Neck Surg. 1992;118:745-748).
AB - In response to infection in the middle ear, inflammatory cells produce cytokines-potent regulators and mediators of the immune response. In an earlier study, we demonstrated that levels of the cytokine interleukin 1 were higher in middle-ear effusions from younger children, while levels of the cytokine tumor necrosis factor were higher in middle-ear effusions from older children and in those requiring tympanostomy on multiple occasions. In this study, we evaluated middle-ear effusions for levels of the cytokine interleukin 6. Activities of interleukin 6 include stimulation of bone erosion and production of antibodies and fever. Using an enzyme-linked immunosorbent assay system, significant levels of interleukin 6 (>0.2 pg/mL) were found in 14 (36%) of 39 middle-ear effusions from 25 children with otitis media with effusion. The mean (±SE) level of interleukin 6 in middle-ear effusions was 173.9± 74.7 pg/mg of total protein. Like interleukin 1, levels of interleukin 6 were higher in younger children. Tumor necrosis factor may be an important regulator of the local immune response in the middle-ear cleft during persistence of otitis media with effusion, while interleukin 1 and interleukin 6 may be important regulators during the early stages of otitis media with effusion. (Arch Otolaryngol Head Neck Surg. 1992;118:745-748).
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U2 - 10.1001/archotol.1992.01880070075014
DO - 10.1001/archotol.1992.01880070075014
M3 - Article
C2 - 1627297
AN - SCOPUS:0026777725
SN - 0886-4470
VL - 118
SP - 745
EP - 748
JO - Archives of Otolaryngology--Head and Neck Surgery
JF - Archives of Otolaryngology--Head and Neck Surgery
IS - 7
ER -