Demographics, Outcomes, and Risk Factors for Patients with Sarcoma and COVID-19: A CCC19-Registry Based Retrospective Cohort Study

on behalf of the COVID-19 and Cancer Consortium

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Patients with sarcoma often require individualized treatment strategies and are likely to receive aggressive immunosuppressive therapies, which may place them at higher risk for severe COVID-19. We aimed to describe demographics, risk factors, and outcomes for patients with sarcoma and COVID-19. Methods: We performed a retrospective cohort study of patients with sarcoma and COVID-19 reported to the COVID-19 and Cancer Consortium (CCC19) registry (NCT04354701) from 17 March 2020 to 30 September 2021. Demographics, sarcoma histologic type, treatments, and COVID-19 outcomes were analyzed. Results: of 281 patients, 49% (n = 139) were hospitalized, 33% (n = 93) received supplemental oxygen, 11% (n = 31) were admitted to the ICU, and 6% (n = 16) received mechanical ventilation. A total of 23 (8%) died within 30 days of COVID-19 diagnosis and 44 (16%) died overall at the time of analysis. When evaluated by sarcoma subtype, patients with bone sarcoma and COVID-19 had a higher mortality rate than patients from a matched SEER cohort (13.5% vs 4.4%). Older age, poor performance status, recent systemic anti-cancer therapy, and lung metastases all contributed to higher COVID-19 severity. Conclusions: Patients with sarcoma have high rates of severe COVID-19 and those with bone sarcoma may have the greatest risk of death.

Original languageEnglish (US)
Article number4334
Issue number17
StatePublished - Sep 2022

Bibliographical note

Funding Information:
M.J.W.—Advisory board Deciphera, Adaptimmune, Epizyme; L.F.—research funding to institution: BMS, Kartos, EMD Serono/Pfizer, Array/Pfizer. Consultant: Else-vier. All outside submitted work; J.C.T.—Blueprint, Deciphera, Bayer, c4 therapeutics, Aadi, Foghorn, Daiichi-Sankyo, Adcendo; A.A.K.—stock ownership Merck, Fate Therapeutics, Exact Sciences, Gilead Sciences, Novavaxi, advisory board Genentech, Research funding to institution Astra Zeneca; A.R.K.—Within the last three years (all unrelated to this manuscript): stock ownership Merck and Sanofi; honoraria from MJH Life Sciences/OncLive and HMP Global; research collaborations with Tempus Labs and Natera; Uncompensated advisory board with Seagen/Astellas; E.A.G.—Honoraria to EAG—Abbvie, Alexion Pharmaceuticals, Genentech, Novartis, CTI biopharma, Apellis, Celgene/BMS, Takeda Oncology, Taiho Oncology, Physician Educational Resource, Med-iCom Worldwide, American Society of Hematology, Picnic Health, AAMDSIF; Research Support to Roswell Park: Astex Pharmaceuticals, Genentech, Blueprint Medicine, Alexion Pharmaceuticals, Apellis, BMS/Celgene, Celldex Therapeutics; I.P.—Within the last three years (all unrelated to this manuscript): consultant fees from Regeneron, Oncorus, Iovance, and Nouscom; stock options from Seneca Therapeutics; W.T.—Personal fees from Eli Lilly, EMD Serono, Mundipharma, C4 Therapeutics, Daiichi Sankyo, Blueprint, Agios Pharmaceuticals, Deciphera, Adcendo, Ayala Pharmaceuticals, Kowa, Servier, Bayer Pharmaceuticals, Epizyme, Cogent, Medpacto, Foghorn Therapeutics, Amgen, AmMax Bio, outside the submitted work; patent Companion Diagnostic for CDK4 inhibitors - 14/854,329 pending to MSKCC/SKI, and a patent Enigma and CDH18 as companion Diagnostics for CDK4 inhibition–SKI2016-021-03 pending to MSKCC/SKI and Scientific Advisory Board - Certis Oncology Solutions, Stock Ownership, Co-Founder - Atropos Therapeutics, Stock Ownership, Scientific Advisory Board Innova Therapeutics; C.H.—Stock holdings in Johnson and Johnson; research funding to institution from Merck, Bausch Health, Genentech, Bayer, and AstraZeneca, consultant fees from Tempus, Genzyme, and EMD Sorono, speaking fees from OncLive/MJH Life Sciences, travel fees from Merck, all outside the submitted work; SRJ—institutional research funding from Varian Medical Systems; M.J.—Research grant—Astrazeneca, Pfizer, Eisai, Advisory board for Seagen, Sanofi; A.K.—Stock holdings Fate Therapeutics, Exact Sciences, Gilead Sciences, Mitati Therapeutics, Novavax; Research funding to institution from Astra Zeneca, Advisory board: Genentech; K.E.—Honoraria from BMS, Pfizer, Merck, Roche, EMD Serono, Astrazeneca, Ipsen, Sanofi, all outside submitted work. Research grants from Pfizer, outside submitted work; L.P.—workshop-Curio Science; advisory board-Epizyme; P.G.—consulting: 4D Pharma PLC, Astellas Pharma, AstraZeneca, Boston Gene, Bristol Myers Squibb, Dyania Health, EMD Serono, Exelixis, Fresenius Kabi, Genentech, Gilead Sciences, Guardant Health, Infinity Pharmaceuticals, Janssen, Lucence Health, Merck, Mirati Therapeutics, Pfizer, Puretech, QED Therapeutics, Regeneron Pharmaceuticals, Roche, Seattle Genetics, Silverback Therapeutics, Uro-Gen; institutional research funding: Bavarian Nordic, Bristol Myers Squibb, Clovis Oncology, Debiopharm Group, EMD Serono, G1 Therapeutics, Gilead Sciences, GlaxoSmithKline, Merck, Mirati Therapeutics, Pfizer, QED Therapeutics; J.L.W.—Consulting-Westat, Roche, Flatiron Health, Melax Tech, outside the submitted work; LLC, outside the submitted work.; E.J.D.- Consulting with Deciphera and Aadi, Speaking fees MJH Life Sciences, Research funding to institution Karyopharm, Top Alliance Biosciences, Cogent, Inhibrx, Actuate, BioAtla, Cornerstone, Incyte; C.H., S.C., B.F., A.B., D.V., E.R., M.I., G.K.S., C.A.P., R.C., C.P., O.Z., V.S., L.T., E.N., E.T.L., C.L., R.M.S., R.R.M., A.A., S.T., B.H., A.A.K., D.Y.R., G.N., H.P., D.K., M.A.B., D.P.S. declared no conflicts relevant to this manuscript. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Funding Information:
REDCap is developed and supported by Vanderbilt Institute for Clinical and Translational Research grant support (UL1 TR000445 from NCATS/National Institute of Health (NIH)). This study was partly supported by grant number P30 CA068485 from the National Cancer Institute to Vanderbilt University Medical Center. Igor Puzanov is supported by NIH (P30CA016056). Petros Grivas is supported by NIH (P30CA015704). The funding sources had no role in the writing of the manuscript or the decision to submit it for publication.

Publisher Copyright:
© 2022 by the authors.


  • CCC19
  • COVID-19
  • SARS-CoV-2
  • sarcoma


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