TY - JOUR
T1 - Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo
AU - Xu, Ting
AU - Falchier, Arnaud
AU - Sullivan, Elinor L.
AU - Linn, Gary
AU - Ramirez, Julian S.B.
AU - Ross, Deborah
AU - Feczko, Eric
AU - Opitz, Alexander
AU - Bagley, Jennifer
AU - Sturgeon, Darrick
AU - Earl, Eric
AU - Miranda-Domínguez, Oscar
AU - Perrone, Anders
AU - Craddock, R. Cameron
AU - Schroeder, Charles E.
AU - Colcombe, Stan
AU - Fair, Damien A.
AU - Milham, Michael P.
N1 - Publisher Copyright:
© 2018 The Authors
PY - 2018/4/10
Y1 - 2018/4/10
N2 - Complementing long-standing traditions centered on histology, fMRI approaches are rapidly maturing in delineating brain areal organization at the macroscale. The non-human primate (NHP) provides the opportunity to overcome critical barriers in translational research. Here, we establish the data requirements for achieving reproducible and internally valid parcellations in individuals. We demonstrate that functional boundaries serve as a functional fingerprint of the individual animals and can be achieved under anesthesia or awake conditions (rest, naturalistic viewing), though differences between awake and anesthetized states precluded the detection of individual differences across states. Comparison of awake and anesthetized states suggested a more nuanced picture of changes in connectivity for higher-order association areas, as well as visual and motor cortex. These results establish feasibility and data requirements for the generation of reproducible individual-specific parcellations in NHPs, provide insights into the impact of scan state, and motivate efforts toward harmonizing protocols. Noninvasive fMRI in macaques is an essential tool in translation research. Xu et al. establish the individual functional parcellation of the macaque cortex and demonstrate that brain organization is unique, reproducible, and valid, serving as a fingerprint for an individual macaque.
AB - Complementing long-standing traditions centered on histology, fMRI approaches are rapidly maturing in delineating brain areal organization at the macroscale. The non-human primate (NHP) provides the opportunity to overcome critical barriers in translational research. Here, we establish the data requirements for achieving reproducible and internally valid parcellations in individuals. We demonstrate that functional boundaries serve as a functional fingerprint of the individual animals and can be achieved under anesthesia or awake conditions (rest, naturalistic viewing), though differences between awake and anesthetized states precluded the detection of individual differences across states. Comparison of awake and anesthetized states suggested a more nuanced picture of changes in connectivity for higher-order association areas, as well as visual and motor cortex. These results establish feasibility and data requirements for the generation of reproducible individual-specific parcellations in NHPs, provide insights into the impact of scan state, and motivate efforts toward harmonizing protocols. Noninvasive fMRI in macaques is an essential tool in translation research. Xu et al. establish the individual functional parcellation of the macaque cortex and demonstrate that brain organization is unique, reproducible, and valid, serving as a fingerprint for an individual macaque.
KW - cortical areas
KW - functional connectivity
KW - gradient
KW - macaque
KW - parcellation
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U2 - 10.1016/j.celrep.2018.03.049
DO - 10.1016/j.celrep.2018.03.049
M3 - Article
C2 - 29642002
AN - SCOPUS:85044599776
SN - 2211-1247
VL - 23
SP - 429
EP - 441
JO - Cell reports
JF - Cell reports
IS - 2
ER -