Delayed pain decrease following M1 tDCS in spinal cord injury: A randomized controlled clinical trial

Aurore Thibaut, Sandra Carvalho, Leslie R. Morse, Ross Zafonte, Felipe Fregni

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Despite some encouraging findings for the treatment of neuropathic pain in patients with spinal cord injury (SCI), transcranial direct current stimulation (tDCS) directed to the primary motor cortex (M1) has faced some mixed results. Prior to translating this technology to clinical care, consistent results and durable effects need to be found. We, therefore, aimed to assess the direct and long-term effects of tDCS on pain following SCI. We performed a two-phase randomized sham-controlled clinical trial where patients received 5 days of tDCS followed by a 3-month follow-up period (Phase I); then, Phase II consisted of 10 days of tDCS with an 8-week follow-up period. We assessed the level of pain with the Visual Analogue Scale (VAS). Patients' quality of life and life satisfaction were also evaluated. 33 patients were enrolled in Phase I and 9 in Phase II. We observed a treatment effect at 1-week follow-up for Phase I and at 4-week follow-up for Phase II. The overall level of pain was significantly lower for the active group, as compared to sham, in Phase II. Our exploratory study shows that tDCS does seem to be a promising tool to manage pain in patients with SCI and repeated stimulation sessions are needed to induce long-lasting effects. Based on our protocol, it appears that adding a second treatment period could induce long-lasting effects. Clinicaltrials.gov identification number: NCT01599767

Original languageEnglish (US)
Pages (from-to)19-26
Number of pages8
JournalNeuroscience Letters
Volume658
DOIs
StatePublished - Sep 29 2017

Bibliographical note

Funding Information:
This project was supported by the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR grant numbers 90DP0035 and H133N110010 ).

Keywords

  • Central sensitization
  • Neuromodulation
  • Pain
  • Spinal cord injury
  • Transcranial direct current stimulation
  • Visual analogue scale

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