Delayed generalized allergic reactions to corticosteroids

Andreas J. Bircher, Paul Bigliardi, Thomas Zaugg, Soili Mäkinen-Kiljunen

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


A 37-year-old patient presented with a severe allergic local reaction upon inhalation of budesonide for asthma. Skin tests were positive for budesonide and amcinonide (group B) and elicited a strong local reaction and a disseminated macular exanthema. Corticosteroids from other groups were well tolerated. A 38-year-old male patient had first an allergic contact dermatitis to topically applied prednisolone acetate and then a disseminated eczematous exanthema upon oral intake of prednisone. A delayed-type sensitization to corticosteroids from group A such as hydrocortisone, prednisone and tixocortol pivalate was identified. A detailed diagnosis in patients with allergic reactions to corticosteroids is crucial with regard to their use in emergency therapy. (C) 2000 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)349-351
Number of pages3
Issue number4
StatePublished - Jan 1 2000


  • Allergic contact dermatitis
  • Allergic exanthema
  • Corticosteroids
  • Cross- reactivity


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