Dehydrogenative cycloisomerization/arylation sequence of heteroatom nucleophile-tethered unactivated alkynes provides a facile and powerful approach to C−C bond formation between the generated heterocycles and unfunctionalized arenes. Here, we describe a hypervalent iodine(III)-catalyzed synthesis of oxazoles concomitant with the introduction of aryl groups into side chain from N-propargyl carboxamides and arenes, representing first C(sp3)−C(sp2) bond formation by the catalytic dehydrogenative cycloisomerization/arylation reaction in exo-dig modes. (Figure presented.).
Bibliographical noteFunding Information:
This work was supported partly by JSPS Fund for the Promotion of Joint International Research (Grant No 16KK0199) and JST CREST (No. JPMJCR19R2). V.V.Z. and A.Y. are thankful to National Science Foundation (CHE‐1759798).
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