TY - JOUR
T1 - Dehydroepiandrosterone sulfate, cortisol, mood state and smoking cessation
T2 - Relationship to relapse status at 4-week follow-up
AU - Ceballos, Natalie A.
AU - al'Absi, Mustafa N
PY - 2006/9/1
Y1 - 2006/9/1
N2 - It has been hypothesized that increased baseline dehydroepiandrosterone sulfate (DHEAS) levels may act as a natural antidepressant to attenuate negative affect during cocaine withdrawal and abstinence, decreasing the probability of relapse. The current study extends this model to assess factors related to risk of relapse in a sample of 68 nicotine dependent participants. Repeated measures ANOVAs were used to examine mood state, salivary DHEAS and cortisol levels across three assessment periods in participants who had relapsed over a 4-week follow-up period (n = 51, 23 women) compared to those who maintained abstinence (n = 17, 8 women). Total scores on the Profile of Mood States differed between those who had relapsed and those who maintained abstinence (p = 0.008). However, DHEAS and cortisol levels, as well as the ratio of cortisol to DHEAS, did not differ significantly between groups. These findings suggest that, although DHEAS-related enhancement of resiliency to withdrawal may occur, the extent of this protective effect may be modulated by additional factors that warrant further research.
AB - It has been hypothesized that increased baseline dehydroepiandrosterone sulfate (DHEAS) levels may act as a natural antidepressant to attenuate negative affect during cocaine withdrawal and abstinence, decreasing the probability of relapse. The current study extends this model to assess factors related to risk of relapse in a sample of 68 nicotine dependent participants. Repeated measures ANOVAs were used to examine mood state, salivary DHEAS and cortisol levels across three assessment periods in participants who had relapsed over a 4-week follow-up period (n = 51, 23 women) compared to those who maintained abstinence (n = 17, 8 women). Total scores on the Profile of Mood States differed between those who had relapsed and those who maintained abstinence (p = 0.008). However, DHEAS and cortisol levels, as well as the ratio of cortisol to DHEAS, did not differ significantly between groups. These findings suggest that, although DHEAS-related enhancement of resiliency to withdrawal may occur, the extent of this protective effect may be modulated by additional factors that warrant further research.
KW - Cortisol
KW - Dehydroepiandrosterone sulfate
KW - Mood
KW - Relapse
KW - Smoking
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UR - http://www.scopus.com/inward/citedby.url?scp=33751196577&partnerID=8YFLogxK
U2 - 10.1016/j.pbb.2006.06.021
DO - 10.1016/j.pbb.2006.06.021
M3 - Article
C2 - 16908055
AN - SCOPUS:33751196577
VL - 85
SP - 23
EP - 28
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 1
ER -