Dehydroascorbic Acid Adducts of Guanosine Residues: Possible Biological Implications

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

In addition to being an antioxidant, ascorbic acid in its oxidized form, dehydroascorbic acid (DHA) can alter DNA or RNA function, such as protein biosynthesis upon binding to guanosine. Here we show the EC50 of DHA on different protein systems and X-ray crystal structure of the isolated adduct of dehydroascorbic acid and 9-ethylguanine (see figure).

Original languageEnglish (US)
Pages (from-to)1015-1017
Number of pages3
JournalChemBioChem
Volume12
Issue number7
DOIs
StatePublished - May 2 2011

Keywords

  • Crystal structure
  • Dehydroascorbic acid
  • Nucleic acids
  • Nucleobases
  • Reticulocytes
  • Vitamins

Fingerprint Dive into the research topics of 'Dehydroascorbic Acid Adducts of Guanosine Residues: Possible Biological Implications'. Together they form a unique fingerprint.

Cite this