Dehydroascorbic Acid Adducts of Guanosine Residues: Possible Biological Implications

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3 Scopus citations


In addition to being an antioxidant, ascorbic acid in its oxidized form, dehydroascorbic acid (DHA) can alter DNA or RNA function, such as protein biosynthesis upon binding to guanosine. Here we show the EC50 of DHA on different protein systems and X-ray crystal structure of the isolated adduct of dehydroascorbic acid and 9-ethylguanine (see figure).

Original languageEnglish (US)
Pages (from-to)1015-1017
Number of pages3
Issue number7
StatePublished - May 2 2011


  • Crystal structure
  • Dehydroascorbic acid
  • Nucleic acids
  • Nucleobases
  • Reticulocytes
  • Vitamins

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