Defining intrinsic vs. extrinsic atopic dermatitis

Chante Karimkhani, Jonathan I. Silverberg, Robert P. Dellavalle

Research output: Contribution to journalComment/debatepeer-review

25 Scopus citations

Abstract

Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin condition characterized by eczematous lesions, i.e. illdemarcated erythematous patches and plaques. AD is commonly associated with elevated immunoglobulin E (IgE) and atopic disorders, such as asthma, hay fever, and food allergies. Rackemann and Mallory were some of the first to distinguish between asthma based on the presence (“extrinsic”) or absence (“intrinsic”) of allergy. This distinction has subsequently been applied to AD based on the presence (“extrinsic”) or absence (“intrinsic”) of increased IgE and atopic disease. Although the distinction between intrinsic and extrinsic AD is widely used, it remains controversial.

Original languageEnglish (US)
JournalDermatology Online Journal
Volume21
Issue number6
StatePublished - 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 by the article author(s).

Keywords

  • Allergy
  • Asthma
  • Atopic dermatitis
  • Eczema
  • Fillagrin

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