Postmortem and genetic studies have clearly demonstrated changes in GABAB receptors in neuropsychiatric disorders such as autism, bipolar disorder, major depression, and schizophrenia. Moreover, a number of recent studies have stressed the importance of cerebellar dysfunction in these same disorders. In the current study, we examined protein levels of the two GABAB receptor subunits GABBR1 and GABBR2 in lateral cerebella from a well-characterized cohort of subjects with schizophrenia (n=15), bipolar disorder (n=14), major depression (n=13) and healthy controls (n=12). We found significant reductions in protein for both GABBR1 and GABBR2 in lateral cerebella from subjects with schizophrenia, bipolar disorder and major depression when compared with controls. These results provide further evidence of GABAergic dysfunction in these three disorders as well as identify potential targets for therapeutic intervention.
Bibliographical noteFunding Information:
Funding for this study was provided by the National Institutes of Mental Health (NIMH), Grant #1R01-MH086000-01A2 (SHF). NIMH had no further role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
Grant support by the National Institutes of Mental Health (Grant # 1R01MH086000-01A2 ) to SHF is gratefully acknowledged. Tissue samples from the Stanley Medical Research Institute to SHF is gratefully acknowledged.
- Bipolar disorder
- GABA receptor
- Lateral cerebellum
- Major depression