TY - JOUR
T1 - Deep brain stimulation in essential tremor
T2 - targets, technology, and a comprehensive review of clinical outcomes
AU - Wong, Joshua K.
AU - Hess, Christopher W.
AU - Almeida, Leonardo
AU - Middlebrooks, Erik H.
AU - Christou, Evangelos A.
AU - Patrick, Erin E.
AU - Shukla, Aparna Wagle
AU - Foote, Kelly D.
AU - Okun, Michael S.
N1 - Publisher Copyright:
© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/4/2
Y1 - 2020/4/2
N2 - Introduction: Essential tremor (ET) is a common movement disorder with an estimated prevalence of 0.9% worldwide. Deep brain stimulation (DBS) is an established therapy for medication refractory and debilitating tremor. With the arrival of next generation technology, the implementation and delivery of DBS has been rapidly evolving. This review will highlight the current applications and constraints for DBS in ET. Areas covered: The mechanism of action, targets for neuromodulation, next generation guidance techniques, symptom-specific applications, and long-term efficacy will be reviewed. Expert opinion: The posterior subthalamic area and zona incerta are alternative targets to thalamic DBS in ET. However, they may be associated with additional stimulation-induced side effects. Novel stimulation paradigms and segmented electrodes provide innovative approaches to DBS programming and stimulation-induced side effects.
AB - Introduction: Essential tremor (ET) is a common movement disorder with an estimated prevalence of 0.9% worldwide. Deep brain stimulation (DBS) is an established therapy for medication refractory and debilitating tremor. With the arrival of next generation technology, the implementation and delivery of DBS has been rapidly evolving. This review will highlight the current applications and constraints for DBS in ET. Areas covered: The mechanism of action, targets for neuromodulation, next generation guidance techniques, symptom-specific applications, and long-term efficacy will be reviewed. Expert opinion: The posterior subthalamic area and zona incerta are alternative targets to thalamic DBS in ET. However, they may be associated with additional stimulation-induced side effects. Novel stimulation paradigms and segmented electrodes provide innovative approaches to DBS programming and stimulation-induced side effects.
KW - Constant current
KW - current steering
KW - deep brain stimulation
KW - essential tremor
KW - posterior subthalamic area
KW - segmented leads
KW - ventralis intermedius nucleus
KW - zona incerta
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U2 - 10.1080/14737175.2020.1737017
DO - 10.1080/14737175.2020.1737017
M3 - Review article
C2 - 32116065
AN - SCOPUS:85080857549
SN - 1473-7175
VL - 20
SP - 319
EP - 331
JO - Expert Review of Neurotherapeutics
JF - Expert Review of Neurotherapeutics
IS - 4
ER -