Decyl bis phosphonate-protein surface modification of Ti-6Al-4V via a layer-by-layer technique

Yu Xiang Ni, Bo Feng, Jianxin Wang, Xiong Lu, Shuxin Qu, Jie Weng

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15 Scopus citations


Titanium and its alloys have been applied in orthopedics due to their biocompatibility, mechanical, and physical properties. Here we use decyl bis phosphonate (DBP) and collagen I to modify Ti-6Al-4V through layer-by-layer technique in order to improve its bioactivity. The abilities of bovine serum albumin (BSA) adsorption and biomimetic mineralization of different sample surfaces were studied. X-ray photoelectron spectroscopy (XPS) and water contact angle data showed that DBP and collagen I were assembled on substrates successfully. The absorbance of BSA solution acquired from ultraviolet spectrophotometer (UV) indicated that samples of Ti-6Al-4V/DBP/Collagen and Ti-6Al-4V/DBP/Collagen/DBP adsorbed BSA most, followed by Ti-6Al-4V/DBP and Ti-6Al-4V. Scanning electron microscope (SEM) photos and X-ray diffraction (XRD) data showed that sample of Ti-6Al-4V/DBP/Collagen had better bioactivity in inducing HA formation than other samples tested in this investigation.

Original languageEnglish (US)
Pages (from-to)4031-4039
Number of pages9
JournalJournal of Materials Science
Issue number15
StatePublished - Aug 2009
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgements This study was jointly supported by the Chinese NSFC (50871093), FANEDD (200554), and National Key Project of Scientific and Technical Supporting Programs funded by MSTC (2006BAI16B01). The authors gratefully acknowledge Dr. Yuancong Zhao for kindly providing guidance in DBP synthesis.


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