Decreasing invasive pneumococcal disease in the elderly: A state-level analysis

Alexander M McBean, Kyoungrae Jung, Paul L. Hebert

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Evidence has accumulated supporting the relationship between the use of 7-valent pneumococcal conjugate vaccine (PCV7) in children and a decline in invasive pneumococcal disease (IPD) in the elderly. We conducted a state-level analysis of vaccination coverage rates among children 19-35 months of age and IPD hospitalization rates among elderly Medicare beneficiaries. Simple correlations were suggestive of a negative relationship. Multivariate analysis using a state fixed-effect model which helped control for the time invariant factors at the state level also indicated a negative relationship, and it was statistically significant, p = 0.035. The relationship between the use of 23-valent pneumococcal polysaccharide vaccine (PPV23) and IPD hospitalizations was not statistically significant using either method.

Original languageEnglish (US)
Pages (from-to)5609-5614
Number of pages6
Issue number27-28
StatePublished - Jul 7 2006

Bibliographical note

Funding Information:
Financial support was provided by the Centers for Medicare and Medicaid Services contract CMS 500-01-0043.

Copyright 2008 Elsevier B.V., All rights reserved.


  • Elderly
  • Invasive pneumococcal disease
  • Pneumonia vaccine


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