Decreases in ADC observed in tissue areas during activation in the cat visual cortex at 9.4 T using high diffusion sensitization

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Recent studies in the human visual cortex using diffusion-weighted functional magnetic resonance imaging (fMRI) have suggested that the apparent diffusion coefficient (ADC) decreases, in contrast to earlier studies that consistently reported ADC increases during neuronal activation. The changes, in either case, are hypothesized to provide the ability to improve the spatial specificity of fMRI over conventional blood-oxygenation-level-dependent (BOLD) methods. Most recently, the ADC decreases have been suggested as originating from transient cell swelling caused by either shrinkage of the extracellular space or some intracellular neuronal process that precedes the hemodynamic response. All of these studies have been conducted in humans and at lower magnetic fields, which can be limited by the signal-to-noise ratio (SNR). The low SNR can lead to significant partial-volume effects because of the lower spatial resolutions required to attain sufficient SNR in diffusion-weighted images. Human studies also have the potential confound of motion. At high magnetic fields and in animal model studies, these limitations are alleviated. At high fields, SNR increases, tissue signals are enhanced and signal changes inside the blood are significantly reduced compared to lower fields. In this work, we were able to measure a small but significant ADC decrease in tissue areas, in conjunction with brain activation in the cat visual cortex at 9.4 T when using highly diffusion-weighted images (b>1200 s/mm2) where intravascular effects are minimal. When using low b-values, delayed increases in the tissue ADC during activation were observed. No significant changes in ADC were observed in surface vessels for any diffusion weighting. Furthermore, we did not observe any temporal differences in the highly diffusion-weighted data compared to BOLD; however, although the changes may likely be vascular in nature, they are highly localized to the tissue areas.

Original languageEnglish (US)
Pages (from-to)889-896
Number of pages8
JournalMagnetic Resonance Imaging
Issue number7
StatePublished - Sep 2008

Bibliographical note

Funding Information:
The authors would like to thank Drs. Peter Andersen and Gregor Adriany for hardware support. This work was supported, in part, by the National Institutes of Health (grants P41RR08079, R01-MH070800, R01 EB000331 and P30 NS057091), the W.M. Keck Foundation and the MIND Institute.


  • ADC
  • BOLD
  • Diffusion
  • Functional mapping
  • fMRI


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