Decreased Infections in Recipients of Unrelated Donor Hematopoietic Cell Transplantation from Donors with an Activating KIR Genotype

Marcie Tomblyn, Jo Anne H. Young, Michael D. Haagenson, John P. Klein, Elizabeth A. Trachtenberg, Jan Storek, Stephen R. Spellman, Sarah Cooley, Jeffrey S. Miller, Daniel J. Weisdorf

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Infectious complications following allogeneic hematopoietic cell transplantation (HCT) from unrelated donors (URD) result in significant morbidity. We hypothesized that recipients of a URD with an activating natural killer cell immunoglobulin-like receptor (KIR) (B/x) genotype would have decreased infectious complications because of enhanced natural killer (NK) cell function. We compared the infectious complications in 116 recipients of a graft from a donor with an A/A KIR (n = 44) genotype and a B/x KIR (n = 72) genotype. All recipients participated in the prospective National Marrow Donor Program infection project collecting infection data from conditioning until 6 months posttransplant. The cohort with a B/x donor had fewer initial bacterial infections by day 180 (A/A: 86%; 95% confidence interval [CI], 75-95; B/x: 68%; 95% CI, 57-78; P = .02). There was no difference in the incidence of viral or fungal infections. When accounting for multiple infections, fewer bacterial infections were seen in the B/x cohort (A/A: 3.55/patient; B/x: 2.63/patient; P = .09). During the study period, only 19 patients had no infections; of these, 15 had received cells from a B/x KIR donor. The role of donor KIR genotype on infection complications is intriguing and warrants further investigation.

Original languageEnglish (US)
Pages (from-to)1155-1161
Number of pages7
JournalBiology of Blood and Marrow Transplantation
Volume16
Issue number8
DOIs
StatePublished - Aug 2010

Bibliographical note

Funding Information:
Financial disclosure: KIR genotyping was supported by NCI grant P01-CA111412 (PI: J. Miller).

Keywords

  • Allogeneic transplantation
  • Infections
  • KIR
  • Unrelated

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