Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment

An sLASER Proton MR Spectroscopy and PiB-PET Study

Burcu Zeydan, Dinesh K Deelchand, Nirubol Tosakulwong, Timothy G. Lesnick, Orhun H. Kantarci, Mary M. Machulda, David S. Knopman, Val J. Lowe, Clifford R. Jack, Ronald C. Petersen, Gulin Oz, Kejal Kantarci

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Glutamate levels may be informative about the declining neuronal health in the central nervous system. We used an advanced proton MR spectroscopy (1H-MRS) protocol composed of semi-localization by adiabatic selective refocusing (sLASER) localization and FAST(EST)MAP shimming for detection of alterations in brain glutamate concentrations in patients with amnestic mild cognitive impairment. METHODS: Participants with amnestic mild cognitive impairment (n = 14; median age = 80) and age- and sex-matched clinically normal controls (n = 32; median age = 79) from the population-based Mayo Clinic Study of Aging were recruited prospectively to the 3T single-voxel 1H-MRS study that examined metabolite changes in the posterior cingulate gyri. To be included, controls had to have low β-amyloid load on [11C] Pittsburgh Compound B (PiB)-PET (standard uptake value ratio; SUVr < 1.42) and patients with amnestic mild cognitive impairment had to have high β-amyloid load (SUVr ≥ 1.42). RESULTS: Glutamate concentration and the glutamate/myo-inositol ratio were lower in patients with amnestic mild cognitive impairment than clinically normal controls (P <.05). Higher global cortical PiB-PET SUVr correlated with lower glutamate/myo-inositol (r = –.3, P =.04). CONCLUSIONS: The advanced sLASER with FAST(EST)MAP shimming is a promising protocol for identifying glutamate alterations. Advanced 1H-MRS protocols may add to the understanding of early Alzheimer's disease pathophysiology through detection of glutamate concentration in posterior cingulate gyri of individuals with amnestic mild cognitive impairment.

Original languageEnglish (US)
Pages (from-to)630-636
Number of pages7
JournalJournal of Neuroimaging
Volume27
Issue number6
DOIs
StatePublished - Nov 1 2017

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Protons
Glutamic Acid
Magnetic Resonance Spectroscopy
Gyrus Cinguli
Inositol
Amyloid
Cognitive Dysfunction
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Alzheimer Disease
Central Nervous System
Health
Brain
Population
Proton Magnetic Resonance Spectroscopy

Keywords

  • Magnetic resonance spectroscopy
  • amnestic mild cognitive impairment
  • glutamate
  • positron emission tomography

Cite this

Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment : An sLASER Proton MR Spectroscopy and PiB-PET Study. / Zeydan, Burcu; Deelchand, Dinesh K; Tosakulwong, Nirubol; Lesnick, Timothy G.; Kantarci, Orhun H.; Machulda, Mary M.; Knopman, David S.; Lowe, Val J.; Jack, Clifford R.; Petersen, Ronald C.; Oz, Gulin; Kantarci, Kejal.

In: Journal of Neuroimaging, Vol. 27, No. 6, 01.11.2017, p. 630-636.

Research output: Contribution to journalArticle

Zeydan, B, Deelchand, DK, Tosakulwong, N, Lesnick, TG, Kantarci, OH, Machulda, MM, Knopman, DS, Lowe, VJ, Jack, CR, Petersen, RC, Oz, G & Kantarci, K 2017, 'Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment: An sLASER Proton MR Spectroscopy and PiB-PET Study', Journal of Neuroimaging, vol. 27, no. 6, pp. 630-636. https://doi.org/10.1111/jon.12454
Zeydan, Burcu ; Deelchand, Dinesh K ; Tosakulwong, Nirubol ; Lesnick, Timothy G. ; Kantarci, Orhun H. ; Machulda, Mary M. ; Knopman, David S. ; Lowe, Val J. ; Jack, Clifford R. ; Petersen, Ronald C. ; Oz, Gulin ; Kantarci, Kejal. / Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment : An sLASER Proton MR Spectroscopy and PiB-PET Study. In: Journal of Neuroimaging. 2017 ; Vol. 27, No. 6. pp. 630-636.
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abstract = "BACKGROUND AND PURPOSE: Glutamate levels may be informative about the declining neuronal health in the central nervous system. We used an advanced proton MR spectroscopy (1H-MRS) protocol composed of semi-localization by adiabatic selective refocusing (sLASER) localization and FAST(EST)MAP shimming for detection of alterations in brain glutamate concentrations in patients with amnestic mild cognitive impairment. METHODS: Participants with amnestic mild cognitive impairment (n = 14; median age = 80) and age- and sex-matched clinically normal controls (n = 32; median age = 79) from the population-based Mayo Clinic Study of Aging were recruited prospectively to the 3T single-voxel 1H-MRS study that examined metabolite changes in the posterior cingulate gyri. To be included, controls had to have low β-amyloid load on [11C] Pittsburgh Compound B (PiB)-PET (standard uptake value ratio; SUVr < 1.42) and patients with amnestic mild cognitive impairment had to have high β-amyloid load (SUVr ≥ 1.42). RESULTS: Glutamate concentration and the glutamate/myo-inositol ratio were lower in patients with amnestic mild cognitive impairment than clinically normal controls (P <.05). Higher global cortical PiB-PET SUVr correlated with lower glutamate/myo-inositol (r = –.3, P =.04). CONCLUSIONS: The advanced sLASER with FAST(EST)MAP shimming is a promising protocol for identifying glutamate alterations. Advanced 1H-MRS protocols may add to the understanding of early Alzheimer's disease pathophysiology through detection of glutamate concentration in posterior cingulate gyri of individuals with amnestic mild cognitive impairment.",
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T2 - An sLASER Proton MR Spectroscopy and PiB-PET Study

AU - Zeydan, Burcu

AU - Deelchand, Dinesh K

AU - Tosakulwong, Nirubol

AU - Lesnick, Timothy G.

AU - Kantarci, Orhun H.

AU - Machulda, Mary M.

AU - Knopman, David S.

AU - Lowe, Val J.

AU - Jack, Clifford R.

AU - Petersen, Ronald C.

AU - Oz, Gulin

AU - Kantarci, Kejal

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N2 - BACKGROUND AND PURPOSE: Glutamate levels may be informative about the declining neuronal health in the central nervous system. We used an advanced proton MR spectroscopy (1H-MRS) protocol composed of semi-localization by adiabatic selective refocusing (sLASER) localization and FAST(EST)MAP shimming for detection of alterations in brain glutamate concentrations in patients with amnestic mild cognitive impairment. METHODS: Participants with amnestic mild cognitive impairment (n = 14; median age = 80) and age- and sex-matched clinically normal controls (n = 32; median age = 79) from the population-based Mayo Clinic Study of Aging were recruited prospectively to the 3T single-voxel 1H-MRS study that examined metabolite changes in the posterior cingulate gyri. To be included, controls had to have low β-amyloid load on [11C] Pittsburgh Compound B (PiB)-PET (standard uptake value ratio; SUVr < 1.42) and patients with amnestic mild cognitive impairment had to have high β-amyloid load (SUVr ≥ 1.42). RESULTS: Glutamate concentration and the glutamate/myo-inositol ratio were lower in patients with amnestic mild cognitive impairment than clinically normal controls (P <.05). Higher global cortical PiB-PET SUVr correlated with lower glutamate/myo-inositol (r = –.3, P =.04). CONCLUSIONS: The advanced sLASER with FAST(EST)MAP shimming is a promising protocol for identifying glutamate alterations. Advanced 1H-MRS protocols may add to the understanding of early Alzheimer's disease pathophysiology through detection of glutamate concentration in posterior cingulate gyri of individuals with amnestic mild cognitive impairment.

AB - BACKGROUND AND PURPOSE: Glutamate levels may be informative about the declining neuronal health in the central nervous system. We used an advanced proton MR spectroscopy (1H-MRS) protocol composed of semi-localization by adiabatic selective refocusing (sLASER) localization and FAST(EST)MAP shimming for detection of alterations in brain glutamate concentrations in patients with amnestic mild cognitive impairment. METHODS: Participants with amnestic mild cognitive impairment (n = 14; median age = 80) and age- and sex-matched clinically normal controls (n = 32; median age = 79) from the population-based Mayo Clinic Study of Aging were recruited prospectively to the 3T single-voxel 1H-MRS study that examined metabolite changes in the posterior cingulate gyri. To be included, controls had to have low β-amyloid load on [11C] Pittsburgh Compound B (PiB)-PET (standard uptake value ratio; SUVr < 1.42) and patients with amnestic mild cognitive impairment had to have high β-amyloid load (SUVr ≥ 1.42). RESULTS: Glutamate concentration and the glutamate/myo-inositol ratio were lower in patients with amnestic mild cognitive impairment than clinically normal controls (P <.05). Higher global cortical PiB-PET SUVr correlated with lower glutamate/myo-inositol (r = –.3, P =.04). CONCLUSIONS: The advanced sLASER with FAST(EST)MAP shimming is a promising protocol for identifying glutamate alterations. Advanced 1H-MRS protocols may add to the understanding of early Alzheimer's disease pathophysiology through detection of glutamate concentration in posterior cingulate gyri of individuals with amnestic mild cognitive impairment.

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KW - glutamate

KW - positron emission tomography

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