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Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma

  • Chani M. Becker
  • , Rajneet K. Oberoi
  • , Stephan J. McFarren
  • , Daniel M. Muldoon
  • , Deanna H. Pafundi
  • , Jenny L. Pokorny
  • , Debra H. Brinkmann
  • , John R. Ohlfest
  • , Jann N. Sarkaria
  • , David A. Largaespada
  • , William F. Elmquist

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Pharmacology, Toxicology and Pharmaceutical Science