La décontamination des organophosphorés : vers de nouvelles alternatives

Translated title of the contribution: Decontamination of organophosphorus compounds: Towards new alternatives

L. Poirier, P. Jacquet, M. Elias, D. Daudé, E. Chabrière

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Organophosphorus coumpounds (OP) are toxic chemicals mainly used for agricultural purpose such as insecticides and were also developed and used as warfare nerve agents. OP are inhibitors of acetylcholinesterase, a key enzyme involved in the regulation of the central nervous system. Chemical, physical and biological approaches have been considered to decontaminate OP. This review summarizes the current and emerging strategies that are investigated to tackle this issue with a special emphasis on enzymatic remediation methods. During the last decade, many studies have been dedicated to the development of biocatalysts for OP removal. Among these, recent reports have pointed out the promising enzyme SsoPox isolated from the archaea Sulfolobus solfataricus. Considering both its intrinsic stability and activity, this hyperthermostable enzyme is highly appealing for the decontamination of OP.

Translated title of the contributionDecontamination of organophosphorus compounds: Towards new alternatives
Original languageFrench
Pages (from-to)209-226
Number of pages18
JournalAnnales Pharmaceutiques Francaises
Volume75
Issue number3
DOIs
StatePublished - May 2017

Keywords

  • Bioremediation
  • Chemical warfare agents
  • Decontamination
  • Enzymes
  • Insecticides
  • Organophosphorus coumpounds
  • Phosphotriesterase
  • SsoPox

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