Decoding powder tabletability: Roles of particle adhesion and plasticity

Research output: Contribution to journalArticlepeer-review

175 Scopus citations

Abstract

Tabletability, the ability to make a tablet of adequate mechanical strength by powder compaction, is of paramount importance in the successful manufacture of tablet products. Poor tabletability is a persistent problem in the pharmaceutical industry. Tablet strength can be understood based on a qualitative model where contributions of bonding area and bonding strength are simultaneously considered. Formation and elimination of bonding area is related to compaction conditions, mechanical properties and particulate properties (such as particle size and shape). Plastic deformation emerges as the most important mechanism for creating a large bonding area among deformation mechanisms. Interfacial adhesion defines bonding strength and is dependent on the chemical nature of the materials involved. An analysis of how the chemical, mechanical and physical properties of a powder impact bonding strength and bonding areas leads to an understanding of their effects on powder tabletability. Appropriate use of this model can minimize empiricism in product development and facilitate the design of high quality tablets and robust manufacturing processes.

Original languageEnglish (US)
Pages (from-to)483-499
Number of pages17
JournalJournal of Adhesion Science and Technology
Volume25
Issue number4-5
DOIs
StatePublished - Jan 1 2011

Bibliographical note

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

  • Powder compaction
  • adhesion
  • bonding area
  • bonding strength
  • plastic deformation
  • surface energy
  • tabletability

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