Decline of Vaccine-Induced Antipneumococcal Antibody in Children With Nephrotic Syndrome

John S. Spika, Neal A. Halsey, Chap T Le, Alfred J. Fish, Gary M. Lum, Brian A. Lauer, Gerald Schiffman, G. Scott Giebink

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Abstract

Twenty-five children with steroid-responsive idiopathic nephrotic syndrome were studied for persistence of antipneumococcal capsular polysaccharide antibody during relapse of their disease and at 1, 6, and 12 months after vaccination with the 14-valent pneumococcal vaccine. Nonrelapsers (group I) were compared to those who had at least one relapse but whose sera were obtained during remission (group II). Group II had a more rapid decline in total anticapsular antibody per month than group I (5.3% v 2.4%). Analysis by individual anticapsular types showed that differences between groups approached significance only for type 4 (P = .07). Rates of decline of antibody against pneumococcal capsular polysaccharide varied among types. One year after vaccination, 50% of patients had < 300 ngAbN/mL against types 4, 6A, 7F 8, and 19F Sera obtained from seven patients during relapse had geometric mean antibody concentrations < 300 ngAbN/mL against those same types; two of these types have been reported to cause disease in vaccinated patients with nephrosis. Decline of antibody against pneumococcal capsular polysaccharide following vaccination varies by capsular type. Type-specific analysis should be used when monitoring serum antibody levels in these patients after vaccination.

Original languageEnglish (US)
Pages (from-to)466-470
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume7
Issue number6
DOIs
StatePublished - Jan 1 1986

Keywords

  • Pneumococcal
  • antibody
  • nephrotic syndrome
  • vaccination

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    Spika, J. S., Halsey, N. A., Le, C. T., Fish, A. J., Lum, G. M., Lauer, B. A., Schiffman, G., & Giebink, G. S. (1986). Decline of Vaccine-Induced Antipneumococcal Antibody in Children With Nephrotic Syndrome. American Journal of Kidney Diseases, 7(6), 466-470. https://doi.org/10.1016/S0272-6386(86)80186-X