Decline of Vaccine-Induced Antipneumococcal Antibody in Children With Nephrotic Syndrome

John S. Spika; Neal A. Halsey; Chap T Le; Alfred J. Fish; Gary M. Lum; Brian A. Lauer; Gerald Schiffman; G. Scott Giebink

doi:10.1016/S0272-6386(86)80186-X

Decline of Vaccine-Induced Antipneumococcal Antibody in Children With Nephrotic Syndrome

John S. Spika, Neal A. Halsey, Chap T Le, Alfred J. Fish, Gary M. Lum, Brian A. Lauer, Gerald Schiffman, G. Scott Giebink

Biostatistics

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Twenty-five children with steroid-responsive idiopathic nephrotic syndrome were studied for persistence of antipneumococcal capsular polysaccharide antibody during relapse of their disease and at 1, 6, and 12 months after vaccination with the 14-valent pneumococcal vaccine. Nonrelapsers (group I) were compared to those who had at least one relapse but whose sera were obtained during remission (group II). Group II had a more rapid decline in total anticapsular antibody per month than group I (5.3% v 2.4%). Analysis by individual anticapsular types showed that differences between groups approached significance only for type 4 (P = .07). Rates of decline of antibody against pneumococcal capsular polysaccharide varied among types. One year after vaccination, 50% of patients had < 300 ngAbN/mL against types 4, 6A, 7F 8, and 19F Sera obtained from seven patients during relapse had geometric mean antibody concentrations < 300 ngAbN/mL against those same types; two of these types have been reported to cause disease in vaccinated patients with nephrosis. Decline of antibody against pneumococcal capsular polysaccharide following vaccination varies by capsular type. Type-specific analysis should be used when monitoring serum antibody levels in these patients after vaccination.

Original language	English (US)
Pages (from-to)	466-470
Number of pages	5
Journal	American Journal of Kidney Diseases
Volume	7
Issue number	6
DOIs	https://doi.org/10.1016/S0272-6386(86)80186-X
State	Published - 1986

Bibliographical note

Funding Information:
From the Department ofPediatrics. University of Minnesota School ofMedicine, and the Department of Biometry. University of Minnesota School of Public Health. Minneapolis; the Department ofPediatrics, University of Colorado, Denver; and the Department of Microbiology and Immunology, State University ofNew York. Downstate Medical Center. Brooklyn. Dr Halsey's current address is the Departments of International Health and Pediatrics, Johns Hopkins University. Baltimore. MD 2/205. Supported in part by Grant No. AI-0882/ and contract NOI 026427 from the National Institute of Allergy and Infectious Diseases. and by grants from the Vikings Childrens Fund and Minnesota Medical Foundation. Address reprint requests to John S. Spika, MD. CJD:DBD:EDB 1-5428, Centers for Disease Control, 1600 Clifton Rd NE, Atlanta. GA 30333. © 1986 by the National Kidney Foundation, Inc. 0272-638618610706-0005$03.0010

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

Pneumococcal
antibody
nephrotic syndrome
vaccination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0272-6386(86)80186-X

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title = "Decline of Vaccine-Induced Antipneumococcal Antibody in Children With Nephrotic Syndrome",

abstract = "Twenty-five children with steroid-responsive idiopathic nephrotic syndrome were studied for persistence of antipneumococcal capsular polysaccharide antibody during relapse of their disease and at 1, 6, and 12 months after vaccination with the 14-valent pneumococcal vaccine. Nonrelapsers (group I) were compared to those who had at least one relapse but whose sera were obtained during remission (group II). Group II had a more rapid decline in total anticapsular antibody per month than group I (5.3% v 2.4%). Analysis by individual anticapsular types showed that differences between groups approached significance only for type 4 (P = .07). Rates of decline of antibody against pneumococcal capsular polysaccharide varied among types. One year after vaccination, 50% of patients had < 300 ngAbN/mL against types 4, 6A, 7F 8, and 19F Sera obtained from seven patients during relapse had geometric mean antibody concentrations < 300 ngAbN/mL against those same types; two of these types have been reported to cause disease in vaccinated patients with nephrosis. Decline of antibody against pneumococcal capsular polysaccharide following vaccination varies by capsular type. Type-specific analysis should be used when monitoring serum antibody levels in these patients after vaccination.",

keywords = "Pneumococcal, antibody, nephrotic syndrome, vaccination",

author = "Spika, {John S.} and Halsey, {Neal A.} and Le, {Chap T} and Fish, {Alfred J.} and Lum, {Gary M.} and Lauer, {Brian A.} and Gerald Schiffman and Giebink, {G. Scott}",

note = "Funding Information: From the Department ofPediatrics. University of Minnesota School ofMedicine, and the Department of Biometry. University of Minnesota School of Public Health. Minneapolis; the Department ofPediatrics, University of Colorado, Denver; and the Department of Microbiology and Immunology, State University ofNew York. Downstate Medical Center. Brooklyn. Dr Halsey's current address is the Departments of International Health and Pediatrics, Johns Hopkins University. Baltimore. MD 2/205. Supported in part by Grant No. AI-0882/ and contract NOI 026427 from the National Institute of Allergy and Infectious Diseases. and by grants from the Vikings Childrens Fund and Minnesota Medical Foundation. Address reprint requests to John S. Spika, MD. CJD:DBD:EDB 1-5428, Centers for Disease Control, 1600 Clifton Rd NE, Atlanta. GA 30333. {\textcopyright} 1986 by the National Kidney Foundation, Inc. 0272-638618610706-0005$03.0010 Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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doi = "10.1016/S0272-6386(86)80186-X",

language = "English (US)",

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AU - Spika, John S.

AU - Halsey, Neal A.

AU - Le, Chap T

AU - Fish, Alfred J.

AU - Lum, Gary M.

AU - Lauer, Brian A.

AU - Schiffman, Gerald

AU - Giebink, G. Scott

N1 - Funding Information: From the Department ofPediatrics. University of Minnesota School ofMedicine, and the Department of Biometry. University of Minnesota School of Public Health. Minneapolis; the Department ofPediatrics, University of Colorado, Denver; and the Department of Microbiology and Immunology, State University ofNew York. Downstate Medical Center. Brooklyn. Dr Halsey's current address is the Departments of International Health and Pediatrics, Johns Hopkins University. Baltimore. MD 2/205. Supported in part by Grant No. AI-0882/ and contract NOI 026427 from the National Institute of Allergy and Infectious Diseases. and by grants from the Vikings Childrens Fund and Minnesota Medical Foundation. Address reprint requests to John S. Spika, MD. CJD:DBD:EDB 1-5428, Centers for Disease Control, 1600 Clifton Rd NE, Atlanta. GA 30333. © 1986 by the National Kidney Foundation, Inc. 0272-638618610706-0005$03.0010 Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

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N2 - Twenty-five children with steroid-responsive idiopathic nephrotic syndrome were studied for persistence of antipneumococcal capsular polysaccharide antibody during relapse of their disease and at 1, 6, and 12 months after vaccination with the 14-valent pneumococcal vaccine. Nonrelapsers (group I) were compared to those who had at least one relapse but whose sera were obtained during remission (group II). Group II had a more rapid decline in total anticapsular antibody per month than group I (5.3% v 2.4%). Analysis by individual anticapsular types showed that differences between groups approached significance only for type 4 (P = .07). Rates of decline of antibody against pneumococcal capsular polysaccharide varied among types. One year after vaccination, 50% of patients had < 300 ngAbN/mL against types 4, 6A, 7F 8, and 19F Sera obtained from seven patients during relapse had geometric mean antibody concentrations < 300 ngAbN/mL against those same types; two of these types have been reported to cause disease in vaccinated patients with nephrosis. Decline of antibody against pneumococcal capsular polysaccharide following vaccination varies by capsular type. Type-specific analysis should be used when monitoring serum antibody levels in these patients after vaccination.

AB - Twenty-five children with steroid-responsive idiopathic nephrotic syndrome were studied for persistence of antipneumococcal capsular polysaccharide antibody during relapse of their disease and at 1, 6, and 12 months after vaccination with the 14-valent pneumococcal vaccine. Nonrelapsers (group I) were compared to those who had at least one relapse but whose sera were obtained during remission (group II). Group II had a more rapid decline in total anticapsular antibody per month than group I (5.3% v 2.4%). Analysis by individual anticapsular types showed that differences between groups approached significance only for type 4 (P = .07). Rates of decline of antibody against pneumococcal capsular polysaccharide varied among types. One year after vaccination, 50% of patients had < 300 ngAbN/mL against types 4, 6A, 7F 8, and 19F Sera obtained from seven patients during relapse had geometric mean antibody concentrations < 300 ngAbN/mL against those same types; two of these types have been reported to cause disease in vaccinated patients with nephrosis. Decline of antibody against pneumococcal capsular polysaccharide following vaccination varies by capsular type. Type-specific analysis should be used when monitoring serum antibody levels in these patients after vaccination.

KW - Pneumococcal

KW - antibody

KW - nephrotic syndrome

KW - vaccination

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Decline of Vaccine-Induced Antipneumococcal Antibody in Children With Nephrotic Syndrome

Abstract

Bibliographical note

Keywords

UN SDGs

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