Decline in influenza-associated mortality among Dutch elderly following the introduction of a nationwide vaccination program

Angelique G.S.C. Jansen; Elisabeth A.M. Sanders; Kristin L. Nichol; Anton M. van Loon; Arno W. Hoes; Eelko Hak

doi:10.1016/j.vaccine.2008.08.003

Decline in influenza-associated mortality among Dutch elderly following the introduction of a nationwide vaccination program

Angelique G.S.C. Jansen, Elisabeth A.M. Sanders, Kristin L. Nichol, Anton M. van Loon, Arno W. Hoes, Eelko Hak

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

With a retrospective nationwide cohort study in the Netherlands over 1992-2003, using mortality and viral surveillance data, the aim was to assess by means of rate difference methods the influenza-associated mortality in the elderly before and after the introduction of a nationwide influenza vaccination program in 1996 (vaccination coverage raised from below 50 to 80%). The average annual influenza-associated mortality declined in the years before and after the introduction from 131 to 105 per 100,000 persons (relative risk 0.80). The decline was largest in the age group 65-69 years (relative risk 0.54) and less in those aged 75 years and older. Validation by Serfling-type regression analysis revealed similar results. In conclusion, routine influenza vaccination among Dutch elderly was associated with a significant decrease in influenza-associated mortality, notably in those aged 65-69 years.

Original language	English (US)
Pages (from-to)	5567-5574
Number of pages	8
Journal	Vaccine
Volume	26
Issue number	44
DOIs	https://doi.org/10.1016/j.vaccine.2008.08.003
State	Published - Oct 16 2008

Bibliographical note

Funding Information:
Dr. Nichol reports having served as a consultant to the influenza vaccine manufacturers Sanofi Pasteur, MedImmune, GSK, and Novartis. Dr. Nichol has received or will receive grant support from Sanofi Pasteur and GSK. This study was funded by the Health Council of the Netherlands.

Keywords

Influenza
Influenza vaccine
Mortality

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2008.08.003

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title = "Decline in influenza-associated mortality among Dutch elderly following the introduction of a nationwide vaccination program",

abstract = "With a retrospective nationwide cohort study in the Netherlands over 1992-2003, using mortality and viral surveillance data, the aim was to assess by means of rate difference methods the influenza-associated mortality in the elderly before and after the introduction of a nationwide influenza vaccination program in 1996 (vaccination coverage raised from below 50 to 80%). The average annual influenza-associated mortality declined in the years before and after the introduction from 131 to 105 per 100,000 persons (relative risk 0.80). The decline was largest in the age group 65-69 years (relative risk 0.54) and less in those aged 75 years and older. Validation by Serfling-type regression analysis revealed similar results. In conclusion, routine influenza vaccination among Dutch elderly was associated with a significant decrease in influenza-associated mortality, notably in those aged 65-69 years.",

keywords = "Influenza, Influenza vaccine, Mortality",

author = "Jansen, {Angelique G.S.C.} and Sanders, {Elisabeth A.M.} and Nichol, {Kristin L.} and {van Loon}, {Anton M.} and Hoes, {Arno W.} and Eelko Hak",

note = "Funding Information: Dr. Nichol reports having served as a consultant to the influenza vaccine manufacturers Sanofi Pasteur, MedImmune, GSK, and Novartis. Dr. Nichol has received or will receive grant support from Sanofi Pasteur and GSK. This study was funded by the Health Council of the Netherlands. ",

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AU - Jansen, Angelique G.S.C.

AU - Sanders, Elisabeth A.M.

AU - Nichol, Kristin L.

AU - van Loon, Anton M.

AU - Hoes, Arno W.

AU - Hak, Eelko

N1 - Funding Information: Dr. Nichol reports having served as a consultant to the influenza vaccine manufacturers Sanofi Pasteur, MedImmune, GSK, and Novartis. Dr. Nichol has received or will receive grant support from Sanofi Pasteur and GSK. This study was funded by the Health Council of the Netherlands.

PY - 2008/10/16

Y1 - 2008/10/16

N2 - With a retrospective nationwide cohort study in the Netherlands over 1992-2003, using mortality and viral surveillance data, the aim was to assess by means of rate difference methods the influenza-associated mortality in the elderly before and after the introduction of a nationwide influenza vaccination program in 1996 (vaccination coverage raised from below 50 to 80%). The average annual influenza-associated mortality declined in the years before and after the introduction from 131 to 105 per 100,000 persons (relative risk 0.80). The decline was largest in the age group 65-69 years (relative risk 0.54) and less in those aged 75 years and older. Validation by Serfling-type regression analysis revealed similar results. In conclusion, routine influenza vaccination among Dutch elderly was associated with a significant decrease in influenza-associated mortality, notably in those aged 65-69 years.

AB - With a retrospective nationwide cohort study in the Netherlands over 1992-2003, using mortality and viral surveillance data, the aim was to assess by means of rate difference methods the influenza-associated mortality in the elderly before and after the introduction of a nationwide influenza vaccination program in 1996 (vaccination coverage raised from below 50 to 80%). The average annual influenza-associated mortality declined in the years before and after the introduction from 131 to 105 per 100,000 persons (relative risk 0.80). The decline was largest in the age group 65-69 years (relative risk 0.54) and less in those aged 75 years and older. Validation by Serfling-type regression analysis revealed similar results. In conclusion, routine influenza vaccination among Dutch elderly was associated with a significant decrease in influenza-associated mortality, notably in those aged 65-69 years.

KW - Influenza

KW - Influenza vaccine

KW - Mortality

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ER -

Decline in influenza-associated mortality among Dutch elderly following the introduction of a nationwide vaccination program

Abstract

Bibliographical note

Keywords

UN SDGs

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