Deceleration of age-specific mortality rates in chromosomal homozygotes and heterozygotes of Drosophila melanogaster

H. Henry Fukui, Lloyd Ackert, James W. Curtsinger

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Age specific mortality trajectories were estimated in mixed-sex cohorts of D. melanogaster. We studied 22,000 flies that were either second- chromosome homozygotes or heterozygotes with a randomized genetic background. Broad-sense heritabilities for longevity were estimated to be 6% for males and 9% for females. Heterozygotes lived longer than homozygotes on average, but there were exceptions to the usual heterotic pattern; in several crosses parental homozygotes had average life spans as long as that of their F1 heterozygotes. Estimated age-specific mortality rates were found to decelerate at advanced ages in both homozygotes and heterozygotes. The mortality models that best fit the data are the logistic model and the two- stage Gompertz model, both of which produce mortality trajectories that level off at advanced ages. Old-age mortality deceleration is not peculiar to inbred Drosophila.

Original languageEnglish (US)
Pages (from-to)517-531
Number of pages15
JournalExperimental Gerontology
Volume31
Issue number4
DOIs
StatePublished - Jan 1 1996

Keywords

  • Gompertz model
  • age-specific mortality
  • logistic model
  • mortality deceleration
  • two-stage Gompertz model

Fingerprint Dive into the research topics of 'Deceleration of age-specific mortality rates in chromosomal homozygotes and heterozygotes of Drosophila melanogaster'. Together they form a unique fingerprint.

Cite this