Decatenation: Fixing your knots

Research output: Contribution to journalComment/debatepeer-review

Abstract

How tumor cells gain resistance to drugs is critically important to elucidate for developing better cancer therapy. In this issue of Blood, Wray and colleagues have identified a mechanism whereby acute leukemia cells use a stimulator of topoisomerase II activity to allow proliferation despite drug inhibition of this essential enzyme.

Original languageEnglish (US)
Pages (from-to)1721-1722
Number of pages2
JournalBlood
Volume114
Issue number9
DOIs
StatePublished - 2009

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