Deamination of cyclaradine by adenosine deaminase under high pressure

Nobuya Katagiri, Hideaki Kokufuda, Masashi Makino, Robert Vince, Chikara Kaneko

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The deamination of cyclaradine corresponding to a carbocyclic analogue of ara-A having anti-HSV activity by adenosine deaminase was examined under various pressure. The deamination of (+)- and (±)-cyclaradine was remarkably facilitated by high pressure, and the rate was increased with increasing of pressure. However, (-)-cyclaradine was not deaminated even under high pressure.

Original languageEnglish (US)
Pages (from-to)81-89
Number of pages9
JournalNucleosides and Nucleotides
Volume17
Issue number1-3
StatePublished - Apr 8 1998

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