De novo design of bioactive protein-resembling nanospheres via dendrimer-templated peptide amphiphile assembly

Brian F. Lin; Rachel S. Marullo; Maxwell J. Robb; Daniel V. Krogstad; Per Antoni; Craig J. Hawker; Luis M. Campos; Matthew V. Tirrell

doi:10.1021/nl202220q

De novo design of bioactive protein-resembling nanospheres via dendrimer-templated peptide amphiphile assembly

Brian F. Lin, Rachel S. Marullo, Maxwell J. Robb, Daniel V. Krogstad, Per Antoni, Craig J. Hawker, Luis M. Campos, Matthew V. Tirrell

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Self-assembling peptide amphiphiles (PAs) have been extensively used in the development of novel biomaterials. Because of their propensity to form cylindrical micelles, their use is limited in applications where small spherical micelles are desired. Here we present a platform method for controlling the self-assembly of biofunctional PAs into spherical 50 nm particles using dendrimers as shape-directing scaffolds. This templating approach results in biocompatible, stable protein-like assemblies displaying peptides with native secondary structure and biofunctionality.

Original language	English (US)
Pages (from-to)	3946-3950
Number of pages	5
Journal	Nano letters
Volume	11
Issue number	9
DOIs	https://doi.org/10.1021/nl202220q
State	Published - Sep 14 2011
Externally published	Yes

Keywords

Peptide amphiphile
biomaterials
dendrimer
protein analog
self-assembly
templating

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10.1021/nl202220q

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abstract = "Self-assembling peptide amphiphiles (PAs) have been extensively used in the development of novel biomaterials. Because of their propensity to form cylindrical micelles, their use is limited in applications where small spherical micelles are desired. Here we present a platform method for controlling the self-assembly of biofunctional PAs into spherical 50 nm particles using dendrimers as shape-directing scaffolds. This templating approach results in biocompatible, stable protein-like assemblies displaying peptides with native secondary structure and biofunctionality.",

keywords = "Peptide amphiphile, biomaterials, dendrimer, protein analog, self-assembly, templating",

author = "Lin, {Brian F.} and Marullo, {Rachel S.} and Robb, {Maxwell J.} and Krogstad, {Daniel V.} and Per Antoni and Hawker, {Craig J.} and Campos, {Luis M.} and Tirrell, {Matthew V.}",

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T1 - De novo design of bioactive protein-resembling nanospheres via dendrimer-templated peptide amphiphile assembly

AU - Lin, Brian F.

AU - Marullo, Rachel S.

AU - Robb, Maxwell J.

AU - Krogstad, Daniel V.

AU - Antoni, Per

AU - Hawker, Craig J.

AU - Campos, Luis M.

AU - Tirrell, Matthew V.

PY - 2011/9/14

Y1 - 2011/9/14

N2 - Self-assembling peptide amphiphiles (PAs) have been extensively used in the development of novel biomaterials. Because of their propensity to form cylindrical micelles, their use is limited in applications where small spherical micelles are desired. Here we present a platform method for controlling the self-assembly of biofunctional PAs into spherical 50 nm particles using dendrimers as shape-directing scaffolds. This templating approach results in biocompatible, stable protein-like assemblies displaying peptides with native secondary structure and biofunctionality.

AB - Self-assembling peptide amphiphiles (PAs) have been extensively used in the development of novel biomaterials. Because of their propensity to form cylindrical micelles, their use is limited in applications where small spherical micelles are desired. Here we present a platform method for controlling the self-assembly of biofunctional PAs into spherical 50 nm particles using dendrimers as shape-directing scaffolds. This templating approach results in biocompatible, stable protein-like assemblies displaying peptides with native secondary structure and biofunctionality.

KW - Peptide amphiphile

KW - biomaterials

KW - dendrimer

KW - protein analog

KW - self-assembly

KW - templating

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M3 - Article

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JO - Nano letters

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De novo design of bioactive protein-resembling nanospheres via dendrimer-templated peptide amphiphile assembly

Abstract

Keywords

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