Abstract
The transprotection of N-Fmoc-cysteine containing di- and tripeptides possessing a free SH group to produce the corresponding S-Fm-cysteine di- and tripeptides bearing a free amino group is accomplished efficiently with DBU in dry THF. The N-Fmoc to S-Fm transformation mechanism is discussed. S-Fm-Cysteine di- and tripeptides readily form amide bonds on coupling with N-(Pg-α-aminoacyl)benzotriazoles and N-(Pg-α-dipeptidoyl) benzotriazoles to give larger peptides.
Original language | English (US) |
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Pages (from-to) | 596-599 |
Number of pages | 4 |
Journal | Organic and Biomolecular Chemistry |
Volume | 9 |
Issue number | 2 |
DOIs | |
State | Published - Jan 21 2011 |
Externally published | Yes |
Bibliographical note
Copyright:Copyright 2011 Elsevier B.V., All rights reserved.