TY - JOUR
T1 - DASH score and subsequent risk of coronary artery disease
T2 - The findings from million veteran program
AU - on behalf of the VA Million Veteran Program
AU - Djoussé, Luc
AU - Ho, Yuk Lam
AU - Nguyen, Xuan Mai T.
AU - Gagnon, David R.
AU - Wilson, Peter
AU - Cho, Kelly
AU - Michael Gaziano, J.
AU - Halasz, Ildiko
AU - Federman, Daniel
AU - Beckham, Jean
AU - Sherman, Scott E.
AU - Sriram, Peruvemba
AU - Tsao, Philip S.
AU - Boyko, Edward J.
AU - Xu, Junzhe
AU - Lederle, Frank
AU - Dellitalia, Louis J.
AU - McArdle, Rachel
AU - Kaminsky, Laurence
AU - DeBakey, Michael E.
AU - Swann, Alan C.
AU - Hamner, Mark B.
AU - Florez, Hermes J.
AU - Pandya, Prashant
AU - Villarreal, Gerardo
AU - Wilson, Peter
AU - Morgan, Timothy R.
AU - Davis, Lori
AU - Bill, W. G.
AU - Hurley, Robin A.
AU - Meyer, Laurence
AU - Ahuja, Sunil K.
AU - Konicki, Eric P.
AU - Cohen, David
AU - Lichy, Jack
AU - Whittle, Jeffrey
AU - Haddock, Kathlyn Sue
AU - Straub, Karl D.
AU - Callaghan, John T.
AU - Aguayo, Samuel M.
AU - Gupta, Samir
AU - Washburn, Ronald G.
AU - Oehlert, Mary E.
AU - Hung, Adriana M.
AU - Wallbom, Agnes
AU - Keith, Robert
AU - Sonel, Elif
AU - Schifman, Ronald B.
AU - Childress, Richard D.
AU - Godschalk, Michael F.
N1 - Funding Information:
This research is based on data from the Million Veteran Program, Office of Research and Development, Veterans Health Administration, and was supported by award CSP# G002. This research was also supported by the VA Merit Award I01-CX001025. This publication does not represent the views of the Department of Veterans Affairs or the U.S. government.
Publisher Copyright:
© 2018 The Authors.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Background--While adherence to healthful dietary patterns has been associated with a lower risk of coronary artery disease (CAD) in the general population, limited data are available among US veterans. We tested the hypothesis that adherence to Dietary Approach to Stop Hypertension (DASH) food pattern is associated with a lower risk of developing CAD among veterans. Methods and Results--We analyzed data on 153 802 participants of the Million Veteran Program enrolled between 2011 and 2016. Information on dietary habits was obtained using a food frequency questionnaire at enrollment. We used electronic health records to assess the development of CAD during follow-up. Of the 153 802 veterans who provided information on diet and were free of CAD at baseline, the mean age was 64.0 (SD=11.8) years and 90.4% were men. During a mean follow-up of 2.8 years, 5451 CAD cases occurred. The crude incidence rate of CAD was 14.0, 13.1, 12.6, 12.3, and 11.1 cases per 1000 person-years across consecutive quintiles of Dietary Approach to Stop Hypertension score. Hazard ratios (95% confidence interval) for CAD were 1.0 (ref), 0.91 (0.84-0.99), 0.87 (0.80-0.95), 0.86 (0.79-0.94), and 0.80 (0.73-0.87) from the lowest to highest quintile of Dietary Approach to Stop Hypertension score controlling for age, sex, body mass index, race, smoking, exercise, alcohol intake, and statin use (P linear trend, <0.0001). Conclusions--Our data are consistent with an inverse association between Dietary Approach to Stop Hypertension diet score and incidence of CAD among US veterans.
AB - Background--While adherence to healthful dietary patterns has been associated with a lower risk of coronary artery disease (CAD) in the general population, limited data are available among US veterans. We tested the hypothesis that adherence to Dietary Approach to Stop Hypertension (DASH) food pattern is associated with a lower risk of developing CAD among veterans. Methods and Results--We analyzed data on 153 802 participants of the Million Veteran Program enrolled between 2011 and 2016. Information on dietary habits was obtained using a food frequency questionnaire at enrollment. We used electronic health records to assess the development of CAD during follow-up. Of the 153 802 veterans who provided information on diet and were free of CAD at baseline, the mean age was 64.0 (SD=11.8) years and 90.4% were men. During a mean follow-up of 2.8 years, 5451 CAD cases occurred. The crude incidence rate of CAD was 14.0, 13.1, 12.6, 12.3, and 11.1 cases per 1000 person-years across consecutive quintiles of Dietary Approach to Stop Hypertension score. Hazard ratios (95% confidence interval) for CAD were 1.0 (ref), 0.91 (0.84-0.99), 0.87 (0.80-0.95), 0.86 (0.79-0.94), and 0.80 (0.73-0.87) from the lowest to highest quintile of Dietary Approach to Stop Hypertension score controlling for age, sex, body mass index, race, smoking, exercise, alcohol intake, and statin use (P linear trend, <0.0001). Conclusions--Our data are consistent with an inverse association between Dietary Approach to Stop Hypertension diet score and incidence of CAD among US veterans.
KW - Coronary artery disease
KW - Epidemiology
KW - Nutrition
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U2 - 10.1161/JAHA.117.008089
DO - 10.1161/JAHA.117.008089
M3 - Article
C2 - 29680824
AN - SCOPUS:85046480021
SN - 2047-9980
VL - 7
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 9
M1 - e008089
ER -
