DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission

A. A. Fienberg; N. Hiroi; P. G. Mermelstein; W. J. Song; G. L. Snyder; A. Nishi; A. Cheramy; J. P. O'Callaghan; D. B. Miller; D. G. Cole; R. Corbett; C. N. Haile; D. C. Cooper; S. P. Onn; A. A. Grace; C. C. Ouimet; F. J. White; S. E. Hyman; D. J. Surmeier; J. A. Girault; E. J. Nestler; P. Greengard

doi:10.1126/science.281.5378.838

DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission

A. A. Fienberg
, N. Hiroi
, P. G. Mermelstein
, W. J. Song
, G. L. Snyder
, A. Nishi
, A. Cheramy
, J. P. O'Callaghan
, D. B. Miller
, D. G. Cole
, R. Corbett
, C. N. Haile
, D. C. Cooper
, S. P. Onn
, A. A. Grace
, C. C. Ouimet
, F. J. White
, S. E. Hyman
, D. J. Surmeier
, J. A. Girault

E. J. Nestler, P. Greengard

Neuroscience

Research output: Contribution to journal › Article › peer-review

412 Scopus citations

Abstract

Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.

Original language	English (US)
Pages (from-to)	838-842
Number of pages	5
Journal	Science
Volume	281
Issue number	5378
DOIs	https://doi.org/10.1126/science.281.5378.838
State	Published - Aug 7 1998

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Fienberg, A. A., Hiroi, N., Mermelstein, P. G., Song, W. J., Snyder, G. L., Nishi, A., Cheramy, A., O'Callaghan, J. P., Miller, D. B., Cole, D. G., Corbett, R., Haile, C. N., Cooper, D. C., Onn, S. P., Grace, A. A., Ouimet, C. C., White, F. J., Hyman, S. E., Surmeier, D. J., ... Greengard, P. (1998). DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission. Science, 281(5378), 838-842. https://doi.org/10.1126/science.281.5378.838

Fienberg, AA, Hiroi, N, Mermelstein, PG, Song, WJ, Snyder, GL, Nishi, A, Cheramy, A, O'Callaghan, JP, Miller, DB, Cole, DG, Corbett, R, Haile, CN, Cooper, DC, Onn, SP, Grace, AA, Ouimet, CC, White, FJ, Hyman, SE, Surmeier, DJ, Girault, JA, Nestler, EJ & Greengard, P 1998, 'DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission', Science, vol. 281, no. 5378, pp. 838-842. https://doi.org/10.1126/science.281.5378.838

@article{3fd1e3d0b0cd4eeca747adcffabbe037,

title = "DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission",

abstract = "Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.",

author = "Fienberg, \{A. A.\} and N. Hiroi and Mermelstein, \{P. G.\} and Song, \{W. J.\} and Snyder, \{G. L.\} and A. Nishi and A. Cheramy and O'Callaghan, \{J. P.\} and Miller, \{D. B.\} and Cole, \{D. G.\} and R. Corbett and Haile, \{C. N.\} and Cooper, \{D. C.\} and Onn, \{S. P.\} and Grace, \{A. A.\} and Ouimet, \{C. C.\} and White, \{F. J.\} and Hyman, \{S. E.\} and Surmeier, \{D. J.\} and Girault, \{J. A.\} and Nestler, \{E. J.\} and P. Greengard",

year = "1998",

month = aug,

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doi = "10.1126/science.281.5378.838",

language = "English (US)",

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pages = "838--842",

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TY - JOUR

T1 - DARPP-32

T2 - Regulator of the efficacy of dopaminergic neurotransmission

AU - Fienberg, A. A.

AU - Hiroi, N.

AU - Mermelstein, P. G.

AU - Song, W. J.

AU - Snyder, G. L.

AU - Nishi, A.

AU - Cheramy, A.

AU - O'Callaghan, J. P.

AU - Miller, D. B.

AU - Cole, D. G.

AU - Corbett, R.

AU - Haile, C. N.

AU - Cooper, D. C.

AU - Onn, S. P.

AU - Grace, A. A.

AU - Ouimet, C. C.

AU - White, F. J.

AU - Hyman, S. E.

AU - Surmeier, D. J.

AU - Girault, J. A.

AU - Nestler, E. J.

AU - Greengard, P.

PY - 1998/8/7

Y1 - 1998/8/7

N2 - Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.

AB - Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.

UR - https://www.scopus.com/pages/publications/0032493904

UR - https://www.scopus.com/pages/publications/0032493904#tab=citedBy

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DO - 10.1126/science.281.5378.838

M3 - Article

C2 - 9694658

AN - SCOPUS:0032493904

SN - 0036-8075

VL - 281

SP - 838

EP - 842

JO - Science

JF - Science

IS - 5378

ER -

DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission

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