d-Amphetamine and phencyclidine alone and in combination

Effects on fixed-ratio and interresponse-time-greater-than-t responding of rats

Alan Poling, James Cleary, Kevin Jackson, Scott Wallace

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The effects of three doses of d-amphetamine (0.5, 1.0, and 2.0 mg/kg) and phencylidine (0.5, 1.0, and 2.0 mg/kg), alone and in combination, were assessed in rats performing under fixed-ratio 30 and interresponse-time-greater-than-15-sec food reinforcement schedules. When given alone, phencyclidine and d-amphetamine produced similar increases in responding under the interresponse-time-greater-than-t schedule, and decreases in responding under the fixed-ration 30 schedule. Each drug decreased the number of reinforcers (food pellets) earned relative to control values under both schedules. The effects of the two drugs in combination were nearly always less than additive. That is, the effects of a given dose of phencyclidine and d-amphetamine together were less than an arithmetic summation of the effects of the drugs given alone.

Original languageEnglish (US)
Pages (from-to)357-361
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume15
Issue number3
DOIs
StatePublished - Jan 1 1981

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Phencyclidine
Dextroamphetamine
Rats
Appointments and Schedules
Pharmaceutical Preparations
Reinforcement Schedule
Food
Drug Combinations
Reinforcement

Keywords

  • d-Amphetamine
  • drug interactions
  • Fixed-ratio schedule
  • Interresponse-time-greater-than-t schedule
  • Operant behavior
  • Phencyclidine
  • Rats
  • Schedule-controlled behavior

Cite this

d-Amphetamine and phencyclidine alone and in combination : Effects on fixed-ratio and interresponse-time-greater-than-t responding of rats. / Poling, Alan; Cleary, James; Jackson, Kevin; Wallace, Scott.

In: Pharmacology, Biochemistry and Behavior, Vol. 15, No. 3, 01.01.1981, p. 357-361.

Research output: Contribution to journalArticle

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