Cytotoxicity and genotoxicity of the carcinogen aristolochic acid I (AA-I) in human bladder RT4 cells

Keyphrases

• 4-aminobiphenyl 12%
• Adduct Formation 6%
• Aristolactam I 12%
• Aristolochic Acid 100%
• Asia 6%
• Bioactivation 12%
• Biochemical Data 6%
• Biodetoxification 6%
• Biological Potency 6%
• Bladder Cancer 18%
• Bladder Cancer Cells 6%
• Bladder Tumor 6%
• Carcinogen 100%
• Chemical Inhibitors 6%
• Cytochrome P450 1A1 (CYP1A1) 6%
• Cytotoxicity 100%
• DNA Adduct Formation 12%
• DNA Adducts 6%
• DNA Damage 6%
• Genotoxic Stress 6%
• Genotoxicity 100%
• Heterocyclic Aromatic Amines 6%
• Human mutations 6%
• Mechanistic Studies 6%
• Mutation Data 6%
• Mutational Signatures 6%
• NQO1 6%
• Omnivore 6%
• P53-dependent Apoptosis 6%
• Smokers 6%
• Toxicity Mechanism 6%
• Transitional Cell Carcinoma 6%
• Transversion mutations 12%
• Tumor Protein p53 (TP53) 12%
• Urinary Bladder 100%
• Urothelial 6%

Pharmacology, Toxicology and Pharmaceutical Science

• 4-Aminobiphenyl 6%
• Aristolochic Acid 100%
• Aristololactam 12%
• Aromatic Amine 6%
• Bioactivation 12%
• Bladder Cancer 18%
• Bladder Tumor 6%
• Carcinogen 100%
• Chemical Inhibitor 6%
• Cytochrome P450 1A1 6%
• Cytotoxicity 100%
• Detoxication 6%
• Genotoxicity 100%
• Malignant Neoplasm 6%
• Omnivore 6%
• Protein P53 6%
• Transitional Cell Carcinoma 6%