Cytotoxic T-lymphocyte antigen-4 single nucleotide polymorphisms are not associated with outcomes after unrelated donor transplantation: A center for international blood and marrow transplant research analysis

Salyka Sengsayadeth; Tao Wang; Stephanie J. Lee; Michael D. Haagenson; Stephen Spellman; Marcelo A. Fernandez Viña; Carlheinz R. Muller; Michael R. Verneris; Bipin N. Savani; Madan Jagasia

doi:10.1016/j.bbmt.2014.03.005

Cytotoxic T-lymphocyte antigen-4 single nucleotide polymorphisms are not associated with outcomes after unrelated donor transplantation: A center for international blood and marrow transplant research analysis

Salyka Sengsayadeth, Tao Wang, Stephanie J. Lee, Michael D. Haagenson, Stephen Spellman, Marcelo A. Fernandez Viña, Carlheinz R. Muller, Michael R. Verneris, Bipin N. Savani, Madan Jagasia

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Cytotoxic T-lymphocyte antigen-4 (CTLA-4) plays an essential role in T cell homeostasis by restraining immune responses. AG and GG genotypes of donor CTLA-4 SNP rs4553808 in patients after unrelated donor hematopoietic stem cell transplantations (HSCT) have been shown to be an independent predictor of inferior relapse-free survival (RFS) and overall survival (OS) compared with those with the AA genotype, in single-center studies. We tested the hypothesis that SNP rs4553808 is associated with RFS, OS, nonrelapse mortality (NRM) and the cumulative incidence of acute graft-versus-host disease (GVHD) and chronic GVHD in adults with acute myeloid leukemia and advanced myelodysplastic syndrome undergoing a first 8/8 or 7/8 HLA-matched unrelated donor HSCT. Multivariable analysis adjusting for relevant donor and recipient characteristics showed no significant association between SNP rs4553808 and OS, RFS, NRM, and incidence of acute and chronic GVHD. An exploratory analysis of other CTLA-4 SNPs, as well as studying the interaction with antithymocyte globulin, also demonstrated no significant associations. Our results indicate that CTLA-4 SNPs are not associated with HSCT outcomes.

Original language	English (US)
Pages (from-to)	900-903
Number of pages	4
Journal	Biology of Blood and Marrow Transplantation
Volume	20
Issue number	6
DOIs	https://doi.org/10.1016/j.bbmt.2014.03.005
State	Published - Jun 2014

Bibliographical note

Funding Information:
The authors acknowledge Cara Sutcliffe, MS Center for Human Genetics Research and Heidi Chen, PhD, Department of Biostatistics for their assistance with this study. Authorship statement : All authors listed participated in the design of the study and the writing of this manuscript. Financial disclosure: This study was supported in part by research funding from Sanofi-Oncology to S.S. and M.J.

Keywords

Cytotoxic T-lymphocyte antigen-4 (CTLA-4)
Hematopoietic stem cell transplantation
Single nucleotide polymorphisms (SNPs)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbmt.2014.03.005

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Sengsayadeth, S., Wang, T., Lee, S. J., Haagenson, M. D., Spellman, S., Fernandez Viña, M. A., Muller, C. R., Verneris, M. R., Savani, B. N., & Jagasia, M. (2014). Cytotoxic T-lymphocyte antigen-4 single nucleotide polymorphisms are not associated with outcomes after unrelated donor transplantation: A center for international blood and marrow transplant research analysis. Biology of Blood and Marrow Transplantation, 20(6), 900-903. https://doi.org/10.1016/j.bbmt.2014.03.005

Cytotoxic T-lymphocyte antigen-4 single nucleotide polymorphisms are not associated with outcomes after unrelated donor transplantation: A center for international blood and marrow transplant research analysis. / Sengsayadeth, Salyka; Wang, Tao; Lee, Stephanie J. et al.
In: Biology of Blood and Marrow Transplantation, Vol. 20, No. 6, 06.2014, p. 900-903.

Research output: Contribution to journal › Article › peer-review

Sengsayadeth, S, Wang, T, Lee, SJ, Haagenson, MD, Spellman, S, Fernandez Viña, MA, Muller, CR, Verneris, MR, Savani, BN & Jagasia, M 2014, 'Cytotoxic T-lymphocyte antigen-4 single nucleotide polymorphisms are not associated with outcomes after unrelated donor transplantation: A center for international blood and marrow transplant research analysis', Biology of Blood and Marrow Transplantation, vol. 20, no. 6, pp. 900-903. https://doi.org/10.1016/j.bbmt.2014.03.005

Sengsayadeth S, Wang T, Lee SJ, Haagenson MD, Spellman S, Fernandez Viña MA et al. Cytotoxic T-lymphocyte antigen-4 single nucleotide polymorphisms are not associated with outcomes after unrelated donor transplantation: A center for international blood and marrow transplant research analysis. Biology of Blood and Marrow Transplantation. 2014 Jun;20(6):900-903. doi: 10.1016/j.bbmt.2014.03.005

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title = "Cytotoxic T-lymphocyte antigen-4 single nucleotide polymorphisms are not associated with outcomes after unrelated donor transplantation: A center for international blood and marrow transplant research analysis",

abstract = "Cytotoxic T-lymphocyte antigen-4 (CTLA-4) plays an essential role in T cell homeostasis by restraining immune responses. AG and GG genotypes of donor CTLA-4 SNP rs4553808 in patients after unrelated donor hematopoietic stem cell transplantations (HSCT) have been shown to be an independent predictor of inferior relapse-free survival (RFS) and overall survival (OS) compared with those with the AA genotype, in single-center studies. We tested the hypothesis that SNP rs4553808 is associated with RFS, OS, nonrelapse mortality (NRM) and the cumulative incidence of acute graft-versus-host disease (GVHD) and chronic GVHD in adults with acute myeloid leukemia and advanced myelodysplastic syndrome undergoing a first 8/8 or 7/8 HLA-matched unrelated donor HSCT. Multivariable analysis adjusting for relevant donor and recipient characteristics showed no significant association between SNP rs4553808 and OS, RFS, NRM, and incidence of acute and chronic GVHD. An exploratory analysis of other CTLA-4 SNPs, as well as studying the interaction with antithymocyte globulin, also demonstrated no significant associations. Our results indicate that CTLA-4 SNPs are not associated with HSCT outcomes.",

keywords = "Cytotoxic T-lymphocyte antigen-4 (CTLA-4), Hematopoietic stem cell transplantation, Single nucleotide polymorphisms (SNPs)",

author = "Salyka Sengsayadeth and Tao Wang and Lee, {Stephanie J.} and Haagenson, {Michael D.} and Stephen Spellman and {Fernandez Vi{\~n}a}, {Marcelo A.} and Muller, {Carlheinz R.} and Verneris, {Michael R.} and Savani, {Bipin N.} and Madan Jagasia",

note = "Funding Information: The authors acknowledge Cara Sutcliffe, MS Center for Human Genetics Research and Heidi Chen, PhD, Department of Biostatistics for their assistance with this study. Authorship statement : All authors listed participated in the design of the study and the writing of this manuscript. Financial disclosure: This study was supported in part by research funding from Sanofi-Oncology to S.S. and M.J. ",

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AU - Wang, Tao

AU - Lee, Stephanie J.

AU - Haagenson, Michael D.

AU - Spellman, Stephen

AU - Fernandez Viña, Marcelo A.

AU - Muller, Carlheinz R.

AU - Verneris, Michael R.

AU - Savani, Bipin N.

AU - Jagasia, Madan

N1 - Funding Information: The authors acknowledge Cara Sutcliffe, MS Center for Human Genetics Research and Heidi Chen, PhD, Department of Biostatistics for their assistance with this study. Authorship statement : All authors listed participated in the design of the study and the writing of this manuscript. Financial disclosure: This study was supported in part by research funding from Sanofi-Oncology to S.S. and M.J.

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Cytotoxic T-lymphocyte antigen-4 single nucleotide polymorphisms are not associated with outcomes after unrelated donor transplantation: A center for international blood and marrow transplant research analysis

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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