Cytotoxic simplified tubulysin analogues

Bhooma Raghavan, Ranganathan Balasubramanian, Jaeson C. Steele, Dan L. Sackett, Robert A. Fecik

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


An efficient route for the synthesis of the tubulysin family of antimitotic peptides was developed. Simplified tubulysin analogues were synthesized to define the minimum pharmacophore required for cytotoxicity. Simplified tubulysin analogues retain significant cytotoxicity and reveal important preliminary structure-activity relationships.

Original languageEnglish (US)
Pages (from-to)1530-1533
Number of pages4
JournalJournal of medicinal chemistry
Issue number6
StatePublished - Mar 27 2008


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