Cytotoxic hydroazulene diterpenes from the brown alga Dictyota dichotoma

Sahar R. Gedara, Osama B. Abdel-Halim, Saleh H. El-Sharkawy, Osama M. Salama, Thomas W. Shier, Ahmed F. Halim

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Two new hydroazulenoid (prenyl guaiane) diterpenes, dictyone acetate (2) and 3,4-epoxy 13-hydroxy pachydictyol A (4) were isolated from the petroleum ether fraction of the alcoholic extract of the brown alga, Dictyota dichotoma (Hudson) Lamouroux, which was collected from the Red Sea coasts at Hurgada, Egypt, together with three known ones, pachydictyol A (1), dictyone (3) and 11-hydroxypachydictyol A (dictyol E) (5). In addition, the steroidal compound, stigmasta-5,(E)-24(28)-dien-3-β-ol (fucosterol) (6) was also isolated. The structures of the isolated compounds have been determined on the basis of spectroscopic evidences as well as physical and chemical correlation with known compounds. Compounds 1, 2, 3 and 5 showed moderate cytotoxic activity.

Original languageEnglish (US)
Pages (from-to)17-22
Number of pages6
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume58
Issue number1-2
DOIs
StatePublished - 2003

Keywords

  • Cytotoxic Hydroazulene Diterpenes
  • Dictyota dichotoma
  • Fucosterol

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