Cytosolic iron chaperones: Proteins delivering iron cofactors in the cytosol of mammalian cells

Caroline C. Philpott, Moon Suhn Ryu, Avery Frey, Sarju Patel

Research output: Contribution to journalShort survey

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Abstract

Eukaryotic cells contain hundreds of metalloproteins that are supported by intracellular systems coordinating the uptake and distribution of metal cofactors. Iron cofactors include heme, iron–sulfur clusters, and simple iron ions. Poly(rC)-binding proteins are multifunctional adaptors that serve as iron ion chaperones in the cytosolic/nuclear compartment, binding iron at import and delivering it to enzymes, for storage (ferritin) and export (ferroportin). Ferritin iron is mobilized by autophagy through the cargo receptor, nuclear co-activator 4. The monothiol glutaredoxin Glrx3 and BolA2 function as a [2Fe-2S] chaperone complex. These proteins form a core system of cytosolic iron cofactor chaperones in mammalian cells.

Original languageEnglish (US)
Pages (from-to)12764-12771
Number of pages8
JournalJournal of Biological Chemistry
Volume292
Issue number31
DOIs
StatePublished - 2017

Fingerprint

Cytosol
Iron
Proteins
Ferritins
Ions
Castration
Glutaredoxins
Metalloproteins
Autophagy
Eukaryotic Cells
Cytoplasmic and Nuclear Receptors
Heme
Sulfur
Carrier Proteins
Metals
Enzymes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

MeSH PubMed subject areas

  • Journal Article
  • Review

Cite this

Cytosolic iron chaperones : Proteins delivering iron cofactors in the cytosol of mammalian cells. / Philpott, Caroline C.; Ryu, Moon Suhn; Frey, Avery; Patel, Sarju.

In: Journal of Biological Chemistry, Vol. 292, No. 31, 2017, p. 12764-12771.

Research output: Contribution to journalShort survey

Philpott, Caroline C.; Ryu, Moon Suhn; Frey, Avery; Patel, Sarju / Cytosolic iron chaperones : Proteins delivering iron cofactors in the cytosol of mammalian cells.

In: Journal of Biological Chemistry, Vol. 292, No. 31, 2017, p. 12764-12771.

Research output: Contribution to journalShort survey

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